Medical discovery proclaims the treatment of aging diseases and neurological disorders

Researchers from South Korea have discovered a role not known for hemoglobin in the brain, which should act as a natural antioxidant that protects neurons from damage. The hemoglobin is a basic protein found in red blood cells in the blood. Its most important function is to transfer oxygen from the lungs to the different tissues in the body, and then transfer carbon dioxide from the tissues to the lungs where they discard. The researchers have developed a new medicine connection, called KDS12025, which strikingly strengthened this role, and managed to delay the progress of diseases such as Alzheimer’s, Parkinson and Atrophic side sclerosis, and also helped to reduce the era of mice during the experiment, and to reduce arthritis, in a performance that have outdated approaches, which are nor, which opens. The study, conducted by a team from the Basic Science Institute (IBS) in South Korea, and published in the journal “Signal Tarzhn and Targt Thirby” asked: Can the protein giving the blood its red color the same the key to the treatment of incurable brain diseases? She ends with the answer to the question by discovering the role of hemoglobin, not only as oxygen transfer in blood cells, but as an antioxidant in the brain cells. In degenerative neurological diseases such as atrophic lateral sclerosis, Parkinson and Alzheimers, in addition to aging, neurons suffer from free radical congestion, especially hydrogen peroxide, which introduces a devastating range of oxidative tension, collects protein, and the collapse of neurons. And when hydrogen peroxide and other free radicals accumulate in the brain in quantities that exceed the ability of cells to get rid of it, these roots become a spark that ignites a complex range of destructive reactions, and it becomes known as oxidative tension, as active molecules become the bisel components of proteins, fats and DNA attacks, their structure weakens their natural functions. While this situation continues, proteins are subject to distortion in their structure, instead of being folded in their exact shape, which guarantees, opens and stuck their right work, and shape abnormal lumps that obstruct cellwork and block their important paths. These protein blocks, which are a prominent feature of diseases such as Alzheimer’s, Parkinson and other degenerative diseases, increase the pressure on neurons and accelerate their damage, and over time, concentrated oxidative stress and protein collects to the collapse of nerve cells, that is, their death and loss permanent, and it leads to memory, dal in motor capacity, Memory and memory have dropped memory, descends into motor capacity, thinking, thinking, and memory and memory of memory, descends, descends in motor capacity, thinking, thinking, and memory and memory of memory, descends, descends in motor capital disorder and behavioral disorder to the full deficit, as in the advanced stages of degenerative diseases. Medical research in the field of degenerative brain diseases has decades focused on trying to control free radicals, the highly interactive molecules that damage nerve cells and speed up their death. The most obvious strategy was the use of traditional antioxidants, such as vitamin E or artificial chemical compounds, in the hope that these substances would pick up free radicals and void its effect. Sudden discovery, but the results were not expected; Most of these compounds cannot cross the blood blood barrier, which is a very strict biological wall that protects the brain from strange substances, but at the same time prevents a lot of medication. Some antioxidants are also chemically unstable, that is, they quickly dissolve before performing their function, and worse, some of them can work randomly, which harms healthy cells instead of protecting it, which ended most of the clinical trials with disappointment. In light of this failure, scientists need different thinking; Instead of introducing external anti -brain, why are the defense systems not already activated? This question led to the sudden discovery that hemoglobin also occurs in the star cells in the brain, and these cells, which form a supportive and critical network for the functioning of neurons, showed that it maintained the levels of hemoglobin in an exact area called the core within its core. In this case; Hemoglobin does not serve as an oxygen carrier, but rather serves as an ‘alternative enzyme’ or ‘internal antioxidant’, and advanced analyzes have shown that hemoglobin is able to decompose hydrogen peroxide – one of the most dangerous forms of free radicals – and it into harmful water molecules. This feature is an internal rescue system that no one expected because it appears that the brain contains a natural mechanism to protect itself from oxidative stress, but it has only been discovered recently. Depending on this discovery, the team, led by Professor Justin Lee, is with Dr. Won Wojin, designed with an innovative, soluble compound in water, and the blood barrier easily crosses the brain, and it is directly related to the HECE Center for Hemoglobin, which has the original function in the transmission of oxygen. Experiences on mice showed incredible and unprecedented results, as the boat managed to slow down the prevalence of symptoms of atrophic lateral sclerosis and increase the average age by more than four weeks compared to the unpaid group, while Parkinson’s models managed to recover the ability to move strikingly. In the case of Alzheimer’s, the animals have seen an improvement in memory and performing cognitive tests, while the average life of elderly mice from two years – which is the normal limit – has increased to about 3 years, and the effects of neurological diseases not only stopped, but also helped and the Rumatoid arthritis helped and reduce. The study concluded that the accumulation of hydrogen peroxide reduced the levels of hemoglobin in the star cells, which weakened the natural defense of the brain and increased its speed of decline, but the innovative compound could convert this equation as IT -hemoglobin, reduced oxidative tension, choir nerves. The hemoglobin tail map so far has no treatment ever targeted hemoglobin in star cells as an anti -oxidant system, making the results wide of this approach a shift in the way to reflect on the treatment of brain diseases associated with aging or auto -immune. “This is an important step in our struggle with nervous degeneration diseases, and by improving internal hemoglobin to counteract oxidative stress, we opened a completely new treatment path,” said the lead author of the study, Justin Lee, director of the Institute’s Cognition and Meeting Center. The research team is now trying to break the mystery of hemoglobin in the brain before turning its idea into a drug that can be given to a person. The researchers say that the puzzle is not limited to the fact that hemoglobin is made up of two similar series, but that each of the alpha series and the beta series has different qualities that may make them perform non -identical roles, and there. Stopping the work of each series separately in the stellar cells in the brain, or increasing and reducing its activity selectively, then monitoring what is happening to the levels of hydrogen peroxide and voltage oxidin and the fate of the neurons itself. The team will compare this natural mechanism and other defense systems with oxidation such as Catalas and Glutathione, to see if there is a stronger range of protection, or it depends on the cooperation of the two series together. The researchers will start working on the development of the KDS12025 basic molecule in a more solid and safe medicine version for people. This means improving its ability to face hydrogen peroxide without causing problems, such as disrupting the essential hemoglobin function in the transmission of oxygen, unwanted association with other protein in the brain, or causing a toxicity in the liver or heart. The research team wants to enable it more to cross the circulatory barrier, more stable in the body, and easier to absorb as you eat, while doing accurate toxicity experiments to ensure its safety. The researchers say the ultimate goal is clear; It is access to an actual remedy that can be tested on larger animals and later on humans.