Are Anti-Oching Products for Real? – ryan
It is an Ancient Dream of Humankind: The Dream of Eternal Youth.
No surprise then, that the world is full of all kinds of “anti-owing treatments”.
A Google Search for this phrase Brings Up Myriad Cosmetic Products, Medical Procedures, Diets and Lifestyle Hacks, All Claiming They Can Help Hold Back the Signs of Advancing Years.
But do these really help US Live Healthier for Longer?
Often, the term “anti-iceing” is used to promote over-the-counter treatments, drugs and supplements that are not supported by regulated clinical studies, such as those conducted for the licensing of drugs for the treatment of other diseases.
There are, however, some serious contenders in the field as well, emerging from the laboratory of geroscientists, ie scientists who work on the biology of aging at the molecular, genetic and cellular levels to understand what makes it a driver for Several Chronic Disas in the elderly.
Exploring Current Drugs
Finding New Drugs and Developing Treatments for Ageing follows the same process as creating medicines for other diseases.
Scientists test chemicals that affect aging or find new uses for existing drugs.
Some of the most promising treatments for extending healthy life include an immunosuppressant drug called rapamycin (also known as sirolimus), an inexpensive diabetes medicine named metformin, and senolytic drugs that selectively eliminate senescent Cells That Stop Dividing But don’t the).
Many of these pharmacological agents have shown Health- team-enhancing effects across multiple animal models and are now being evaluated in clinical trials.
Rapamycin was initially prescribed as an immunosuppressive agent after kidney transplants.
It has been shown to extend lifespan in diverse animal models by activating autophagy, the process by which the body’s cells clean out damaged components.
One much-anticipated clinical study in the coming years is the targeting aging with metformin (tame) trial, which is being planned across 14 Leading Research Institutions in the United States and will involve 3,000 participants aged 65–79 years.
The study will take six years to complete.
Metformin is an approved drug for the treatment of diabetes, but has been shown to target multiple ages.
Among other things, it lowers insulin levels and reduces DNA (deoxyribonucleic acid) Damage.
Senolytics are a class of therapeutics that aid in Clearing Senescent cells that accumulate with age and contribute to age-related diseases.
Studies on Senotherapeutic drugs in preclinical models have paved the way for ongoing clinical trials in patients with serious health conditions such as diabetes, Alzheimer’s Disease and Frailty.
Early-Stage Clinical Trials with Senolytics have shown and allviation of frail in Humans, as well as modulation of the progression of Alzheimer’s Disease.
On the Cellular Level
Another approach to drug Discovery involves investigations of populations in “blue zones”, which are places whose inhabitants exhibit exceptional longevity.
Also Read: Blue Zone Bluff: Could all those centenarians not be as old as we thought?
The rationale behind this approach is that enhanced longevity correlates with the delayed oneset of age-related diseases and may be influenced by inherent protective molecular factors.
Thus, identifying genetic variants linked to HealthSpan could lead to the discovery of interventions that promote Healthy aging.
A relatively new method that may reverse aging in cells is chemically-induced reprogramming, which can make old cells behave like Young ones.
This discovery is a cost-effective alternative to genes therapy for rejuvenating cells and could have far-reeaching effects on injury repair and the treatment of age-related diseases.
Studies in Preclinical Models have highlighted the role of a class of non-coding rna (ribonucleic acid) molecules in aging.
One recent study uncovered the role of a microrna, mir-302b, in Rejuvenation in Ageing Mice.
Injecting Mice with this RNA Molecule increased their life team, promoted hair regrowth and helped maintain their physical and mental abilities.
This microrna facilitates rejuvenation by restoring cell division in Senescent Cells.
Future clinical trials are needed to test the utility of this rna therapy in reversing aging in humans, but the results look promising.
Cosmetic Changes Only
At the Biological Level, aging leads to a progressive decline in function due to an accumulation of errors in the cells and tissues that constitute our bodies, ultimately increasing the risk of disability and disease.
Skin aging involves the development of finine lines and wrinkles, loss of elasticity, discolouration, and rough texture.
Cosmetic treatments such as anti-wrinkle creams, serums and dermal fillers can improve skin appearance.
These treatments are temporary, and there is no scientific evidence to support the reversal of aging through them.
Liposuction is a frequently-used cosmetic surgical procedure for removing excess subcutaneous fat to enhance body contours.
In the context of aging, liposuction is not effective at reducing visceral fat, which is a major concern in age individuals.
Also Read: Too much fat can affect Brain Power
Lifestyle modifications such as diet and exercise are the best-known methods to reduce visceral fat.
Moreover, published evidence examining the impact of surgically-induced cosmetic treatments such as liposuction on metabolic health factors, indicates that this procedure does not improve metabolic abnormalities associated with obesity.
An increasing need
Research indicates that older populations are growing worldwide.
It is predicted that by 2030, every sixth person in the world will be aged 60 and above.
By 2050, two-thirds of the world’s population over the age of 60 will live in low and middle-income countries.
The increase in the older population relative to Younger Individuals presents significant challenges due to the increased frequency of age-related medical issues that will not only require trained geriatricians, but also a better understanding of the aging process.
Although People are living longer, many spending their later years in Poor Health.
Their additional years are often overshadowed by a decline in physical and cognitive health.
Older People Can Experience A Wide Range of Physical and Mental Disabilities, and Many suffer from Chronic Diseases.
This highlights the need for approaches that focus on the biological causes of aging, understanding what happens at the molecular, genetic and cellular levels, since age is a driver for several chronic diseases simultaneously in the elderly.
News regarding anti-iceing therapies is often exagrated and promoted by the media, as the idea of a single pill or therapy that could prevent aging and increase longevity is appealing to many people.
For researchers interested in the biomedical aspects of aging, the key motivation lies in the enormous potential to design gerotheraputics that can counter-related diseases simultaneously.
While research in the past two decades has narrowed down a few possible candidates, clinical human data will be needed before these can be registered as drugs.
Diet control
As we wait for the clinical validation of new methods, some feasible and promising approaches to improving HealthSpan and slowing age-related disabilities included, diet and lifestyle factors.
While overeating and obesity are associated with accelerated aging, many species that undergo dietary restriction – or administered significantly less than they would easily if given unrestricted access – have a longer lifespan, reduced cancer risk and delayed ages.
Specific Dietary Interventions tested in short-term clinical trials include the Mediterranean Diet, Fasting-Mimicing Diets and Caloric Restriction.
Caloric restriction, intermittent facing and time-restricted feeding are different ways of practicing dietary restriction, which remains the only known reproducible strategy for increasing Lifespan Across All Animal Models Studide. – 360info
Associate Professor Dr Geetanjali Chawla is a Molecular Biologist at the Shiv Nadar Institution of Eminence, Delhi-Ncr, India.