A potential antibiotic from the skin of catfish to treat stomach cramps

Researchers, from the skin of the planted African fish, have withdrawn a compound “with strong traits” against some kind of bacteria that cause stomach pain and cramps, according to a new study announced at the University of California, Davis, on Sunday. Although additional tests are needed, to prove the effectiveness and safety of the compound, the study uses when used as a ‘potential’ antibiotic in the future, that one day it can be a strong new tool against bacteria resistant to large -scale antimicrobials. The boat, ‘Pet time’ called Nacap-II, showed strong antibacterial properties against a common and dangerous strain of antibiotic-resistant bacteria, which is ‘coli’ that attacks the small intestine, and causes symptoms such as colic, diarrhea and painful abdominal contractions. This study, conducted by a post -phd researcher, Hidmun Okila, at the University of California, Davis, is an ‘important step in searching for new weapons against drug -resistant pathogens’, according to a university press release. Okila said that the global threat to public health due to antimicrobial resistance requires the search for new safe and effective anti -bacterial compounds, and in this case “antimicrobial peptides derived from fish is a promising source of potential vehicles.” The scientific article was published at the activities of the Authoric Society for Biochemistry and Molecular Biology. The researchers withdrew many peptides, which are short chains of amino acids, from the mucus of the skin of the African fish, and used machine leather algorithms to investigate it in search of a possible antibacterial activity. These tests showed that the new compound led to bacteria decomposing or killing, without damaging blood cells in mammals. Initial results indicate that this promising peptide filter is likely to disrupt the bacterial cell covering, leading to its decomposition with very low concentration. How does the new boat work? During laboratory tests; The new composite interaction with the bacterial cell membrane through electrostatic reactions, as many antimicrobial peptides are negatively attracted to the surface of the bacterial bacterial cell. Once attached to the bacterial cell membrane, the compound disrupts the structure of the binary fatty layer, causing the stability and permeability of the membrane. Due to this imbalance, the basic cell ingredients leak from the bacterial cell, which in the end leads to cell analysis and bacterial death. Irrigation Xianism, according to “Mayo Clinic”, people can be exposed to the infection of the coli from water, or food infected with bacteria, especially raw vegetables and mince, inappropriate. Healthy adults often recover from the coli infection within a week. But children and the elderly are more at risk of life -threatening infection with renal failure due to infection. The indicators and symptoms of irritable coli usually begin to appear after 3 or 4 days of exposure to bacteria. But you may have a disease after bacteria, ranging from one day to a week or more. The signs and symptoms include: diarrhea, which can range from light, severe and bloody, as well as stomach cramps, or a feeling of pain or pain if you touch it, nausea and vomiting, in some people. Antibiotic resistance and according to the World Health Organization, antibiotic resistance is one of the biggest challenges facing human health around the world as it can significantly affect health, food security and development. The use of antibiotics in an uncertainty in an increase in bacterial resistance rates, which makes the treatment of infection more difficult, and this can lead to increased medical costs and high mortality rates. The organization itself indicates that antibiotic resistance is rapidly increasing around the world, which is a major challenge for our ability to effectively treat infectious diseases, increase the risk of aggravation of general medical conditions and double the need for new antibiotics present. The new peptide is found in the mucus on the skin of the planted of the condensed African fish, and protects this mucus, the fish against infection by removing the germs from the skin, or by producing antimicrobial compounds, such as those that are the research team isolated. Many medications depend on compounds found in nature for the first time, and scientists expect marine and water organisms to represent a particular source, although not largely used, for biologically active compounds. As a next step, researchers plan to study the effects of peptide in animal models and to investigate its production strategies at a low cost. Okila says that the team is currently using chemical synthesis to increase the production of this peptide, “which we think will one day be useful as a nominee in the fight against antimicrobial resistance.”