A new genetic treatment for heart failure achieves 'impressive results' during experiments

A team of researchers has reached a new genetic treatment that can reflect the effects of heart failure and almost completely restore its functions, in an experiment conducted on a large animal model. According to the study published in the journal “Nature” on Tuesday, the treatment showed impressive results as it improved the heart of the heart to pump blood and significantly increased the survival rates. The researchers described the results as “an unprecedented recovery of the function of the heart”. And the failure of the heart is a chronic disease that causes the heart’s weakness to pump the blood adequately, and it is considered until the announcement of these recent research results is a non -healing condition, except by planting a new heart. Currently, the available treatments focus on relieving the pressure on the heart and delaying the progress of the disease. However, this new genetic treatment offers the hope that almost a quarter of the world population will have a heart failure at some point in their lives, according to the study. The researchers focused on an important protein called CBIN1, the level of which is low in patients with heart failure. This deficiency exacerbates the disease and increases the risk of death. The researchers decided to test what happened during the recovery of the levels of this protein. CBIN1 protein works CBIN1 as an important regulator, or ‘as of signals’, as it controls a wide variety of other proteins that are important for the heart muscle function, by reorganizing the heart cells and rebuilding its internal structure, helping to restore important heart functions. Using a safe virus used in genetic treatments, scientists have brought an additional version of the gene responsible for the production of CBIN1 to the heart cell. The experiment, performed on pigs suffering from heart failure, showed impressive results. All animals that received treatment survived for six months, which is the maximum experiment, compared to the normal rate that leads to death within two months. The impact of treatment was not limited to the prevention of the decline of the condition of the heart, but rather showed significant improvement in some standards of heart function, as the improvement of blood pump efficiency, which is the most important indication of the risk of heart failure, increased by 30%, compared to only 5-10% in previous treatments. The hearts that underwent treatment showed an improvement in its external structure as it became less stretched, and closer to the appearance of healthy hearts. “In the history of research on heart failure, we have not seen an event like this before,” the study writer, Robin Show, and director of the Noura Eccils Harrison Research Institute at the University of Utah. Despite promising results, the treatment must undergo toxicity tests and other safety procedures. There is also an additional challenge is the effectiveness of treatment in people who have developed a natural immunity to the virus used to transfer the gene. What is heart failure? Heart failure occurs when the heart muscle does not pump as it should. If it occurs, the blood bounces often, and fluid can accumulate in the lungs, which according to “Mayo Clinic” causes self -sufficient. Some patients associated with the heart gradually cause to weaken the heart, or to suffocate it with some extent that affects the ability to extract blood and pump. These patients include narrowing the veins of the heart and high blood pressure. The appropriate treatment can improve, symptoms of heart failure, and it can help extend the life of the heart in some people. Lifestyle changes, such as weight loss, exercise, reduction of salt intake and tension control, can improve the quality of the heartwork. But heart failure can be life -threatening, and people with heart failure can prevent severe symptoms. Some people may need to undergo heart implants, or install a device to help the heart pump blood.