Researchers develop a treatment for cancer using "glue"

Researchers at the University of Tokyo have revealed an innovative way to improve the treatment of head cancer and advanced neck, using polyvinyl alcohol (PVA), which according to a recent study is a common component of glue. The study, published in Journal of Controlled Release, showed that the combination of this type of glue with a boat containing drilling, called D-BPA, increases the effectiveness of a specific type of targeted radiotherapy, compared to the medicine currently used to treat cancer. The treatment, known as ‘treatment of neutrons by drilling’, depends on the target of cancer cells without damaging healthy cells. Buron -containing connections play an important role in cancer treatment; Since it represented the materials targeted by low -energy neutrons, such as when neutrons interact with boron cells in cancer cells, the reaction produces devastating radiation that kills the affected cells without damaging other cells, provided the congestion and selectivity are sufficient, and the condition of the combination of high selectivity and effective accumulation to ensure the success of the treatment. Patients initially become a remedy to treat cancer, and get a medicine that contains drills designed to build up in cancer cells, and then patients are exposed to low -energy neutrons, which interact with cancer cells. This method is characterized by targeting only drill -containing cells, which reduces damage to healthy tissues, and makes it effective at repeated cancers, or those that are difficult to treat. The success of the treatment is very dependent on the extent of the drilling concentration in the cancer cells, and the ability to stay there during the treatment period. Currently, the compound known as “Para-Porono Vinyl Alanin” is the only substance currently adopted in the treatment of neutrons captured by drill, and this compound works by picking it up in the cancer cells as the crop absorbs it more because of the high altar activity compared to healthy cells. But the problem is that this compound can also leak in healthy cells near the crop, especially in areas where the crop is surrounded by sensitive tissues. A unique composition This leak leads to the exposure of healthy cells to radiation during treatment, which increases the risk of side effects, and reduces the effectiveness of treatment in some cases. Researchers have been trying to use a substance called D-BPA for years, which is the molecular counterpart of L-BPA, as it has a chemical composition that forms a mirror image of the compound currently used, and is characterized by the high selectivity of cancer cells compared to L-BPA, making it an attractive option to reduce the potential damage to healthy cells. But the main disadvantage of D-BPA lies in the inability to build up the cancer cells alone. This deficit makes it ineffective as an independent treatment, which is why it was considered invalid in the technique. The polyvinyl alcohol is a commonly used compound in many industries, including the gum industry, and this type is characterized by a safe and non -toxic polymer, making it suitable for use in medical applications. In the study, the researchers used this compound as a supportive substance to improve the properties of the D-BPA connection, as the glue is combined with the D-BPA connection to form a unique binary composition, which increases the accumulation of D-BPA in the cancer cells as the traditional compounds currently used. The target of cancer cells This integration depends on the ability of PVA to increase the stability of the compound in the body, which extends the period of its survival in the cancerous tumor, and when the glue is combined with D-BPA, the first serves as a mediator who selects the second to the cancer cells, which reduces the accuracy in healthy cells, use of the techniques, which use the use of using the use of the techniques that use the use of the use of the techniques, which are the effective use of the city, which is using the use of the techniques, which is the struggle, the goal of using the stading of the stating ability. by drilling. The researchers believe that the glue D-BPA makes an effective and safe alternative to cancer treatment, while improving selectivity, reducing the side effects on healthy cells, and adding glue to the D-BPA connection to improve the accumulation of the drill in cancer cells, increasing the duration of retaining it. The lead author of the study, Takahiro Nomoto, says that the development of medicine to counter this complex disease faces major challenges, especially with the increasing direction in the design of complex and expensive molecular structures. He explains: “Despite the possibilities of this treatment approach, it can lead to heavy costs that make it useful to a limited number of patients.”