Cheap dust doubles the power of antibiotic 10,000 times to kill bacteria

A recent study found that the combination of traditional antibiotics, and a simple molecule called ‘chlorosis’ can be a new entrance point for the treatment of chronic wounds that are difficult to heal, and at the same time allow a way to improve the effectiveness of current medication against resistance bacteria. The study, prepared by the American University of Oregon researchers and published by the applied and environmental microbiology, showed that the addition of small doses of chlorine to antibiotic in laboratory experiments, making them 10,000 times more effective to kill bacteria compared to their own use. These results open the door for therapeutic strategies that can reduce the duration of antibiotics, reduce their doses, thus reducing toxicity and side effects. Experiments focused on bacteria known as pseudomonas aeruginosa, which is one of the microorganisms that settle chronic wounds, hinder healing and are known for its major resistance to antibiotics. These bacteria especially affect the sores caused by diabetes, such as diabetic feet, which affect one in every 4 patients with type 2 diabetes, according to the data of the American Diabetes Society. In almost half of these cases, the infection develops seriously, while one in 5 patients is forced to perform amputation. The research team explained that this is the apparent risk, as chronic wounds do not lead to disability and the loss of limbs, but also patients before the risks of doubling and the decrease in the quality of life. Chronic wounds are defined as those that do not begin to recover during a period of between 4 and 12 weeks, and remain open and exposed to further decline. There are many biological causes behind the healing wounds, including poor blood flow, and the high need for immune cells to oxygen with bacteria at the place of the injury, which reduces the amount of oxygen available for tissues. The poor oxygen environment is the biggest challenge before antibiotics, as it inherently reveals the mechanisms of resistance and endurance to bacteria, when the oxygen decreases, bacteria to gain a “nitrate breath” to gain energy, and although their growth in this case is slowed, still surviving it and makes it less vulnerable to the traditional effects of antibiotic. -Rich environments, according to Melanie Spero, the leader of the research team. Chlons are a group of chemical chemical compounds that contain chlorine one and are an ion consisting of a chlorine atom associated with three oxygen atoms, and these compounds are known for their high ability to release oxygen when exposed to heat, or in certain circumstances, which make them strong oxidizing materials used in industrial fields and sometimes as antiseptics. Although the chlorine in high doses may be toxic, recent research has indicated that the use of very small doses of biological pressure on some types of bacteria can cause, which makes it more sensitive to antibiotics. The study came as an extension of previous research conducted by Spearo at the California Institute of Technology, which for the first time noticed the Chlors’ ability to turn the bacteria against bacteria in cell cultivation and mouse models with diabetes. She explained: “Until now, it seems that the compound is the ability of bacteria to take advantage of nitrates in the absence of oxygen, but it not only eliminates them in all circumstances. But along with antibiotics, they create an internal environment for bacteria that cannot tolerate double pressure, so it cannot provide resistance.” The pharmaceutical synergy was not only limited to one antibiotic, but also included several types, which means that the strategy can be common and not related to a specific drug. “Here is its importance in light of the increasing global challenge of resisting antibiotics,” says Speer. While researchers around the world create new generations of medicine, the team of this study provides another idea that relies on the revival of the effectiveness of old medicine by integrating it with simple particles with an integrated effect. Such an approach can reduce the urgent need to discover new complicated and expensive vehicles, and this allows the benefit of the arsenal of already available medicine, but the way to clinical application is still long, as Spearo confirms that experiments in the laboratory have been conducted on cellular farms, while chronic infection is in fact more difficult because it includes different microbial communities. The researchers said that the next step is to test these structures in closer models than reality, such as animals that mimic the human wound environment, before later transferring to clinical trials on patients. The study emphasized that the understanding of the molecular mechanisms is accurate, it is an urgent necessity, as it is not sufficient to monitor the end result of killing bacteria without knowing the internal interactions that lead to it. Spearo explained that the way to design rational medicines by detecting ‘vital devices’ that is pressure in the cell goes through. This work is part of a scientific effort that escalates in the light of the so -called ‘antibiotic crisis’, according to recent estimates, bacteria that are resistant to hundreds of thousands of deaths annually, and it can become the largest health threats worldwide, if radical solutions are not developed. The researchers bet on the principle of “pharmaceutical synergy”, that is, the search for combinations that make existing medication more efficient than they are individually, and if the understanding of the mechanisms of this synergy is achieved, as Spearo hope, it will not only be an “guess” to experiment with every possible composition, but rather a rational design on accurate mechanical mechanical. Since it is proven that the chlorine improves the performance of antibiotics against the pseudo bacterial bacteria, the results are likely to apply to other types of stubborn bacteria that are increasingly concerned in hospitals around the world. The chlorine is a long and inexpensive material for a long time, which is easy to use when adopted medically, but there is another need to prove their long -term safety, and to ensure that unexpected side effects do not occur in complex biological environments. “These results will have important consequences, not only about the treatment of chronic wounds, but also in the field of infectious diseases, and our fight against antibiotics and the failure of treatments,” says Spearo. She explained that achieving a better understanding of medicine -synger -mechanisms the search for other molecules that increase similar behavior, leading to a new era of ‘rational medicine design’ using previously approved compounds.