How can you correct the DNA yourself? A study that reply

A research team from the British University of Berlingham has managed to disclose accurate details setting out two complicated mechanisms to repair DNA damage, which can open the door for significant improvements in future cancer treatments. Two separate studies, published in the journal “Nature Communications”, and “Molecular Cell”, emphasize how cells are organized to accurately recover DNA, which protects the body from pathogenic mutations. DNA reform of an essential important process, which does cells to recover damage that occurs in its molecules due to various factors such as ultraviolet radiation, chemicals or even natural errors during the cell section. The reform process maintains genetic stability and guarantees the transfer of genetic information accurately from one cell to another. Without an effective recovery mechanism, mutations collect in DNA, which can lead to serious illnesses such as cancer, genetic disorders or even cell death. DNA recovery and the importance of the recovery process lies in the fact that it works as a first line of defense to protect living organisms from damage to damage to damage, and contributes to the conservation of organs and body tissue, and also plays an important role in resisting aging and regenerating cells. DNA recovery systems are also an important target for medical research, as they can be used to improve cancer treatments by preventing cancer cells from recovering their genetic damage, making it more sensitive to different treatments. Each cell in the human body contains an accurate monitoring system to discover and repair DNA damage. If damage is done, the cell sends internal signals to determine the location of the damage, and it asks for specialized proteins that work as ‘repair machines’. But this process must be accurately organized, as the right proteins must reach the appropriate amounts and at the ideal time. Many cancer treatments, such as chemotherapy, are used by this mechanism by damaging the DNA of cancer cells to prevent their reproduction. Improving cancer treatment medicine, the first author of the study, Joe Morris, professor of molecular inheritance at the University of Birmingham, said that “these discoveries help us understand how cells are recovered from damaged DNA, and as many cancer treatments depend on the damage of DNA, these results can lead to the improvement of current treatments and the development of new more effective drugs.” The first study focused on a protein called RNF168, known as its role in sending DNA recovery signals. RNF168 is one of the most important proteins in the cell as it works as a DNA guard, and plays a major role in protecting the cell when any damage occurs, or cut into the DNA, if damage to the DNA occurs, the location on the other one after the exact location of the problem. It also helps to strengthen these warning signals to ensure that a sufficient number of recovery proteins have reached the damaged location. Thus, the RNF168 protein plays a decisive role in organizing the recovery process, as it recovers in the right way in time, which protects the cell from errors that can lead to diseases such as cancer. This protein also works with accuracy, so that the warning signals do not remain too much or less than necessary to maintain the exact balance in the cell. But the problem is that this protein can cause excessive signals if not stopped in time, disrupting the arrival of other recovery proteins to the damage yard. ‘SMITATION KEY’ The researchers have discovered a mechanism called ‘the key to turn’, a process of 4 steps that change the form of protein to stop the activity, and experiments have shown that the cells that do not have this mechanism become very sensitive to radiation, which impedes DNA recovery. As far as the second study is concerned, previous assumptions are challenged on a protein known as Sumo4, which was almost useless. The researchers found that this protein plays a decisive role in preventing the imbalance of DNA reform signals, as other signals are disrupted, which prevents some proteins from recovering the damage yard, and that reform is therefore failed. The researchers pointed out that Sumo4 protein plays an important role in regulating cellular processes within the body, as it serves as an important ‘chemical sign’ that controls the activity of other protein. Protein is associated with other protein, and adapt the way it works, affecting many important processes, including the immune response, and transfer of cellular signals, especially the process of repairing DNA damage, and it also has a major role in preventing the imbalance of DNA reform signals, as it works as an accurate organizer in a way Recovery protein reaches, and without the cell losing the ability to lose the ability. Sumo4 is also linked to inflammatory reactions, and it can play a role in some immune diseases such as type 1 diabetes, making it a promising goal of future medical research in various areas ranging from cancer treatment and immune diseases. Cancer -fighting efforts and research have warned that a profound understanding of the microscopic mechanisms that control DNA recovery proteins can represent a qualitative shift in the fight against cancer, as it opens new horizons to improve the current chemical treatments, and makes it more accurate to target cancer cells without harming healthy cells. The study paves the way for developing a new generation of smart medication that disrupts the ability of cancer cells to restore their DNA damage, making them more fragile and weak before different treatments. The discovery is also a leading step towards achieving personal medicines in the treatment of crops, as assigned treatments for each patient can be designed based on the understanding of the mechanisms of DNA recovery in its cancer cells, which increase the effectiveness of treatment, and reduce its unwanted side effects, which represent a new hope for millions of patients.