A new scientific penetration proclaims the treatment of incurable brain diseases

Researchers at the Ican College of Medicine on Mount Sinai managed to develop innovative technology, which could treat treatments safely and effectively. This technique, studied on mouse models and isolated human brain tissue, is a great progress in the treatment of a wide variety of neurological and psychological diseases. The study, published in the journal “Nature Biotechnology”, assesses the effectiveness of a new system, known as the system of vehicles that cross the blood blood barrier, which is the first of its kind to overcome this obstacle that prevents large molecules from reaching the central nervous system. The new technology depends on a specialized biological process called transmission by the cells, which enables the delivery of large therapeutic molecules, such as protein, through simple venous injection. The circulatory -barrier is a complex physiological structure, which consists of a network of dense covenant cells in the walls of the blood vessels that feed the brain. This barrier works as a natural shield that prevents the access of harmful substances and toxins of the blood to the tissue of the brain, which maintains a stable and appropriate environment for the functions of the central nervous system, but it allows the passage of basic nutrients such as glucose and amino acids while limiting the entrance of unwanted vehicles. The blood blood barrier despite its decisive role in the protection of the brain, the circulatory barrier is a major challenge in nerve medicine; As it also occurs the entry of many medications and treatments that are essential for the treatment of the disease of the central nervous system, and that means that the barrier is not only selective against toxins, but it is also a hindrance to medicine with large molecules such as proteins. Due to the blood blood barrier, many neurological diseases remain difficult to treat, including Alzheimer’s, Parkinson and atrophic side sclerosis. “The brain blood barrier is a basic defense mechanism, but it is also a major obstacle to the delivery of medication to the brain. Our system breaks this obstacle, which allows the delivery of large molecular treatments to the central nervous system in a safe and effective way. Blood blood barrier without disrupting its function, or damaging it. is, and if the molecule is linked to the future, it is placed in the cell by the internal transport process, as the vesicle containing the molecule is formed. Inside the cell, the gamma secretes enhance the membrane proteins associated with the transport process, as the pieces allow the editing of the vesicle and transport it over the cell to the other side. Once the vesicle is transferred on the other side of the cell, the therapeutic molecule is released in the targeted area, such as the brain tissue. This system helps to overcome natural barriers that prevent large medications and molecules from reaching protected organs such as the brain, and these mechanism can be used to produce genetic remedies that target certain genes associated with disease. Unlike the traditional methods that temporarily open the opening of the blood blood barrier, the transfer by that enzyme keeps the septum intact, reducing the risk of infections or side effects. Alzheimer’s treatment and atrophic lateral sclerosis In the study, researchers inject a compound called BCC10 linked to specialized genetic instruments, known as anti -allergic olegonocyotides. The compound showed effectiveness in reducing the activity of harmful genes in the brain. In a mouse model with atrophic lateral sclerosis, the treatment could reduce the levels of the gene that cause the disease known as SOD1 and the highly associated protein. Another boat associated with BCC10 has also reduced a MAPT gene, which is responsible for producing ‘Tao’ protein, an important goal for Alzheimer’s treatment and other dementia. The BCC10 system has shown that it is a high effectiveness to deliver genetic tools to the brain, which strengthens the ability to put out harmful genes in various models, including human brain tissue samples. More importantly, the treatment is well tolerated in mice, and there is no significant damage to the main organs of the tested doses. The researchers say that the new technology can solve one of the biggest obstacles in brain research, which is delivering large therapeutic molecules to the brain. This development opens new horizons to treat a wide range of brain diseases.