A study reveals a new hope for eliminating "Lyme" disease

Researchers have revealed the discovery of an enzyme that may be an ideal purpose to develop new treatments against ‘Lyme’ disease, and probably against other ticks transmitted by ticks. The results published in the Journal of the American Association for Microbiology are an important step towards a better understanding of the mechanisms to retain the pathogens of ticks and develop effective treatments. “Lyme” is the most common disease that transmits ticks in the United States and Europe, caused by a bacterial infection caused by bacteria known as “Borillia Burjorfiri”. These bacteria have a unique ability to adapt to their environment as they have developed complicated metabolic roads that enable them to stay within the tick body for long periods and then move to humans or other host animals at the bite. This disease is characterized by a multi -phase, as it usually begins with the rise of a distinctive rash that looks like the bull’s eye in the sting of the sting, but it can later develop to include more severe symptoms, such as joint pain, nerve inflammation, nervous system disorders and heart. The danger of bacteria and what makes these bacteria dangerous is their ability to avoid the immune system as it changes from its superficial structure to avoid the immune response of the body, which allows it to multiply, without the body easily eliminating it. The complex Lict Life cycle, which includes different stages of the larvae for the adult insect, provides bacteria with an ideal environment for the transmission between families, without losing its ability to infection, and for this reason, to control “Lyme” disease, several strategies are needed, including the prevention of ticks, early diagnosis and immediate antibiotic treatment. With the increasing rate of infection over the past year due to environmental changes and the increase in the number of ticks, the search for new vaccines or treatment methods has become more urgent than ever, especially in light of the presence of some cases that do not respond to traditional treatment, and turned into chronic cases whose symptoms last years. Consequently, the concept of the complex interaction between bacteria and ticks, and the host body is an essential step towards more effective treatments, which limits its spread and its serious complications. The ticks go through three main phases in his life cycle, “Al -Yarqa, Al -nahriya and Al -Aadab”, and at each stage of these stages, the ticks need a blood meal to complete the growth and develop to the next phase, and if the ticks cause the bacteria that “Lyme” can be transferred to the new host, Bite. If a tick bites a person, bacteria go the bloodstream through the sniva, and it usually lasts between 36 and 48 hours after the tick sticks to the skin, and it quickly removes the risk of disease. After the bacteria enter the body, it begins to spread through the bloodstream and tissues, leading to the occurrence of symptoms of “Lyme” disease if the infection is not treated quickly and effectively. In the previous research conducted by scientists from the University of Virginia community, it was discovered that the bacteria of “Borily Burgdorfiri”, which cause “Lyme”, have unique metabolic roads that differ from most of the other bacteria. Unlike many living organisms based on thiamine, vitamin B1 as an essential assistant factor in metabolic reactions, it appears that these bacteria do not use thiamine at all. Instead, it depends on an enzyme called ‘lactate dehydrogenase’ to do the process of transforming pirovate into lactate. This process is of very important importance as it plays a major role in maintaining a balance between important connections in the cell, known as (NADH, NAD+), and is necessary for oxidation and reduction that controls the production of cellular energy. Thanks to this unique adjustment, “Borillia Burgdorfiri” can remain in low nutritional environments, such as ticks, and then move to the human body and continue with its activity without relying on the traditional nutritional sources that most other bacteria need. The development of medicine in the new study identified researchers the role of lactate dehydrogenase in the pathological physiology of these bacteria and explored the possibility of using it as a new treatment objective. Using a group of technologies, including genetics, biochemistry and the study of X -Ray crystals, researchers have enabled the researchers to clarify the biochemical and structural chemical properties of this enzyme. The study showed that this enzyme is needed for the growth of bacteria in the laboratory and the ability to infection in living organisms. The researchers also conducted a very productive investigation to discover new enzyme charges, and they were able to identify several promising vehicles. While research continues, these results can lead to the development of new medicines aimed especially at these enzyme, reducing side effects, and improving the efficacy of treatment, and these discoveries can also help develop new preventative strategies against tick diseases.