Organic Acid Diseases: Causes, Symptoms and Treatment

Organic acid diseases sponsored by organic acid diseases are a group of genetic disorders containing a defect in the metabolic process of protein due to a lack or inefficiency of one of the biological enzymes in the process, and this leads to the accumulation of a toxic chemical or other chemical deficiency needed for the right work of the body. The effect of this deficiency is related to the time of symptoms of the disease, the light deficiency, the more symptoms it appears. The metabolism crisis can also appear a few days after proper birth, while symptoms may occur in mild cases as fever or during fasting. Early diagnosis and treatment can quickly prevent damage and help to live naturally. Common diseases of organic acids are one of the most important types of common diseases as follows: Glutaric acidemia Type 1. Isvaleric acidemia. Methylmalonic acidemia. Proper acidemia. Multiple carboxylase shortcoming. The path of glucocarian lean disease is different, so that the initial growth of the child is healthy, but if the child has a fever, hypothony develops in the muscles, reduced consciousness and ultimately a disorder in the movement of dystonia and spiritual decline. Symptoms of organic acid diseases There are many symptoms and signs of organic acid diseases represented by the following: 1. Symptoms of organic acid diseases include symptoms of the disease as follows: Loss of appetite. Vomiting. Quick breathing. Muscle tension. Changes to the degree of awareness. The condition of the patient deteriorates to the coma (coma). Epilepsy grabs. Ultimate death. 2.. Signs of organic acid diseases, and the metabolic crisis is accompanied by biochemical changes, including: asidosis. The high concentration of ammonia in the blood. Low the number of blood cells of all blood cell species. Carnitine. High level of organic acids for the disease in the urine. Causes and factors of the risk of organic acid diseases The person is exposed to organic acid diseases due to the genetic factor, as all these disorders are considered inherited in the form of a recessive physical trait, and as a genetic disorder, the parents of the child with one of these cases are not infected, but they are pregnant with the disease and have one natural and abnormal. In each pregnancy, parents who carry the injured no different chances of having an infected or healthy child should have as follows: a 25% chance of having a child in two versions of the abnormal gene and the organic acid appears. A 50% chance of having a pregnant child who is not affected by the carrier parents. 25% chance of having an infected and non -pregnant child. These relationships apply to each pregnancy, and tests must be performed for all brothers who have been diagnosed with an organic acid disorder, and the genetic consulting services must be provided to the family. Complications of organic acid diseases if previous disorders are not treated, including health problems, including: brain damage. coma. Eye problems. Visual loss. Spiritual and developmental disabilities, which are problems associated with how the brain works, that a person can cause a problem or delay in physical growth, learning, communication, care for himself or exist with others. Osteoporosis, where the bones become thin and fragile. Heart problems, liver, kidneys or pancreas. Entology. Stroke. Death if untreated. Diagnosis of organic acid diseases is diagnosed with amino acid diseases as follows: 1. Diagnosis of the fetus infection during pregnancy The diagnosis can be performed during pregnancy between the eighth and tenth week by examining the samples of the chorionic villus sampling, or between the 16-20 week, by the breastfeeding pellet or what is known as amniocentisis. 2.. Diagnosis of infection in children in some countries. A newborn examination of organic acid disorders is performed using tandem -mass cyctrutry to detect the high levels of asylinine. It is possible to obtain false positive and negative results with this investigation, but the collection of samples early after the first 24 hours of life can improve the discovery of these disorders, as the levels of Asyl -Carnein may fall as the life of the baby increases. Babies who are supposed to undergo positive examination tests need a quick follow -up and the baby is converted into a specialist in metabolic diseases. The treatment of organic acid diseases is usually treated as follows: 1. After an appropriate healthy system that includes immediate treatment of the metabolic crisis, includes: Stop eating foods that contain amino acids that the body cannot analyze. Provide a large amount of calories that are with fat and sugar. The sufficient diet for the patient later, so that it contains little natural protein, and added to it, special nutrients that do not contain amino acids that the body cannot analyze. 2.. Add some types of vitamins and supplements. The following vitamins are added to treat disease: Vitamin B12 (B12): For Metayl leather. Biotin: For carboxyllas. Glycine: For an oniswuzenic acid disease. In most cases, two carcinogenic therapy is added. 3.. Dialysis. In some cases, dialysis is needed to drain toxic acids and provide supportive care. The prevention of organic acid diseases is difficult to prevent genetic diseases, such as: organic acid diseases, but diagnosis and early treatment help improve quality of life and avoid complications.