Huntington's disease .. A recent study with a new hope for patients

A recent study conducted by researchers at the University of Oxford revealed an important mechanism associated with the development of Huntington’s disease, which can pave the way for the discovery of the disease before its clinical symptoms appear and stop its progress. The study was published in the “Nature Metabolism” magazine, as it for the first time the biochemical change responsible for the development of this disease, and how to stop its progress by stopping this change. Huntington’s disease is a genetic disorder, which gradually affects the functions of the brain, leading to mental and physical decline that has worsened over time. The symptoms of Huntington’s disease begin with the symptoms of Huntington’s disease to appear after the age of thirty and are deadly, but the disease can continue to affect the patient up to 20 years, causing a greater decline in health condition. The early symptoms of Huntington include involuntary and anomal movements, as well as problems in balance and pronunciation exacerbated by the development of the disease. Over time, the disease leads to serious damage to certain parts of the brain, especially in areas responsible for motor and cognitive control. Despite the great progress in understanding the physiological changes of Huntington, the disease is still without treatment, which confirms the need to provide diagnostic and therapeutic interventions before the symptoms appear, and this study may be a step in this direction. The new study took how early biological change in the brain of Huntington patients, discovered in the 1980s, could lead to the beginning of the occurrence of the disease. The neurons and Huntington disease. The researchers concluded that the neurons, known as the ISPNs, are the first cells affected by Huntington’s disease, can contribute to the imbalance of dopamine levels in the brain when losing an important signal from the activation of receptors known as “TKB” for nerve growth. Forced nerve cells in the indirect track are a kind of neurons in a part of the brain, known as the scheme, which plays a decisive role in regulating movement and motor control. These cells impede the movement, which enables exact control of physical movements, which prevent excessive or unwanted movements. In Huntington’s disease, these neurons are affected early, leading to an imbalance in dysfin and other neurological signaling systems, and this imbalance causes symptoms such as involuntary movements and other motor symptoms that occur early in people with Huntington disease. According to the researchers, Dopaming Fek is responsible for the early symptoms of Huntington, such as involuntary movements. Cellular energy balance, researchers have studied mice suffering from an imbalance in the function of these neurons, due to the disturbance of TKB receptors, and mice showed high levels of dopamine in the brain, which led to an increase in motor activity, and this change was striking before the rise of the symptoms of the disease. The researchers also found that a protein known as GSTO2, an enzyme involved in the metabolism of a chemical transmission called glutathione, plays an important role in regulating dopamine levels, and this protein plays an important role in the regulation of dopamine levels in the brain, and it affects the balance of cellular energy. The researchers also found that the irregularity of the GSTO2 action leads to a defect in dopamine levels, and energy metabolism disorders, which contribute to the emergence of early kinetic symptoms of the disease. In this study, scientists indicate that controlling the activity of this protein may be a possible way to slow down or prevent the development of symptoms of Huntington’s disease; When the researchers reduced the activity of this enzyme in mice, they could prevent dopamine imbalances and energy disorders, which stopped the rise of motor symptoms in the mice. The researchers say that these enzyme shows similar disorders in the Huntington mouse model, as well as in some of the brain of patients who have not yet appeared, confirming its potential role in developing this disease. The development of Huntington’s disease and, according to researchers, it is the first time that scientists have been able to determine a specific chemical change, which distinguishes the development of Huntington’s disease, which opens the door to develop tests that study early changes in the disease before irreparable damage occurs. Thanks to this discovery, it may soon be possible to study Huntington’s disease in very early stages, and perhaps clear symptoms appear. This means that future developments may include new diagnostic instruments for the early detection of biochemical changes that characterize Huntington’s disease, which opens the door for innovative treatments that target these changes in their early stages.