Study connects magnesium supplements to growth in gut bacteria and reduced risk of colorectal cancer, especially in women

In findings from a precision-oriented clinical trial, researchers at the Vanderbilt University Medical Center revealed that magnesium supplementation increases bowel bacteria for the synthesis of vitamin D and possibly reducing the risk of colorectal cancer, as reported by Medical Xpress. Results were published in the American Journal of Clinical Nutrition. The effect was most expressed in women, with researchers suggesting that estrogen may be a mechanism to improve magnesium’s cellular uptake, and thus its effects. Magnesium’s effects on intestinal microbes and vitamin D synthesis build this clinical trial on preceding evidence that supplementation with magnesium increases the blood levels of vitamin D. But this trial has shown that magnesium also increases vitamin D synthesis in the intestines, whose local consequences can help reduce risk factors associated with colorectal cancer, even in the absence of sunlight. The trial examined the effects of magnesium supplement on the microbial data of the intestines associated with the presence of the TRPM7 pleasure, which regulates the cellular absorption of both magnesium and calcium. As noted in Medical Xpress, the results provide a preliminary link between magnesium and a reduced risk of colorectal cancer in key populations. Gender -based response to magnesium supplement The researchers noted that the influence of magnesium supplement in women was more clear. The researchers argued that estrogen could be a central player in moving magnesium from circulation to cellular uptake, increasing the microbial activity in the intestines. In participants with adequate TRPM7 function, there was a significant increase in the levels of beneficial bacteria, including Carnobacterium maltaromaticum and Faecalibacterium prausnitzii, who are known to work together to improve the production of vitamin D and reduce the risk of colorectal cancer. Consequences of preventing colorectal cancer The trial consisted of 236 individuals, all of which had a history of colorectal polyps. The median follow-up time was 3.5 years after-colonoscopic. In those with sufficient TRPM7 function, increased F. prausnitzii in rectal mucosa was associated with a triple increase in the chance to develop additional polyps. It was reassuring that those in the insufficient TRPM7 function group, when supplemented with magnesium, had a reduction in F. prausnitzii in rectal mucous membrane, proving that magnesium could help reduce the risk of colorectal cancer for those with a genetic predisposition. This groundbreaking study paves the way for precision-based strategies in the prevention of colorectal cancer, and emphasizes the important role of magnesium and intestines in the mitigation of cancer risk. Questions How does magnesium supplement affect the risk of colorectal cancer? Magnesium supplementation increases the gut bacteria that synthesize vitamin D, which can help reduce colorectal cancer risk by affecting the intestines locally without sunlight. Why is the effect more outspoken at females? Researchers suggest that estrogen can play a role in improving magnesium’s cellular uptake, the increasing microbial activity in the intestines and the promotion of vitamin D synthesis. How does TRPM7 function relate to the effectiveness of magnesium? TRPM7 regulates magnesium and calcium uptake; Individuals with adequate TRPM7 function have seen increased beneficial bacteria, which may reduce the risk of colorectal cancer.