The three scientists have been recognized ‘for their groundbreaking discoveries regarding peripheral immune tolerance that prevent the immune system from harming the body’, the Nobel Committee said. (LR) The portraits of Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi are shown at a press conference where the winners of the 2025 Nobel Prize for Physiology or Medicine are announced on October 6, 2025. relating to the immune system. These findings have opened new possibilities for research and developing therapies for cancer and auto -immune diseases. The Nobel meeting at the Karolinska Institutet in Stockholm announced on Monday that Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi will share the 11 million Krona ($ 1.2 million) price. 2025 Nobel laureates in medicine: All you need to know Mary E. Brunkow (USA): She holds the post of senior program manager at the Institute for Systems Biology in Seattle, USA. She and Fred Ramsdell are credited with the most important discovery of the FoxP3 gene, which shows that a mutation in this gene causes a serious auto -immune disease (IPEX) and is very important for funnel function. Fred Ramsdell (USA): He is the Chief Scientific Officer at Sonoma Biotherapeutics, a company in San Francisco that focuses on the development of engineering regulatory T cell therapies. Ramsdell’s work, along with Brunkow, was central to connecting the FOXP3 to immune regulation. Shimon Sakaguchi (Japan): He is a prominent professor at the Immunology Frontier Research Center (IFREC) at Osaka University, Japan. He is best known for his initial discovery and characterization of regulatory T cells, which shows their indispensable role in maintaining self-tolerance. The three scientists were recognized “for their groundbreaking discoveries regarding peripheral immune tolerance that prevent the immune system from harming the body,” the Nobel Committee said. They “identified the security guards of the immune system, regulatory T -cells, and thus laid the foundation for a new research field”. In a social media post on X, the official handle of the Nobel Prize said: “Mary Brunkow and Fred Ramsdell – who received the 2025 Nobel Prize for Physiology or Medicine – gained decisive insights into how auto -immune diseases arose. mouse) auto -immune diseases. The discoveries also led to the development of possible medical treatments now evaluated in clinical trials, the committee noted.
Medicine Nobel 2025 awarded to Mary Brunkow, Fred Ramsdell and Shimon Sakaguchialles on the American Japanese Trio
