Manu Joseph: There is crushing news for people who want to live for a long time

Copyright © HT Digital Streams Limit all rights reserved. Menning Manu Joseph 4 min Read 20 Apr 2025, 02:00 Ist Bryan Johnson does different experiments on himself in his attempt to live a very long time like a young man. Summary a wonder drug called Rapamycin that a wealthy man named Bryan Johnson tested on himself on himself was possibly a dudd. Or at least he gave it up. “A few days ago, Bryan Johnson, a Senti millionaire who spent millions on the reversal of the age-especially put his own bad news for humanity on his YouTube channel. Rapamycin, who has long been the most promising molecule in our quest to extend the youth, did not make him younger; Instead, it “accelerated” his aging. Johnson, who is 47 and looks 46, does different experiments about himself in his attempt to live a very long time like a young man. I trust in Him. His food consumption is so calibrated that he knows the number of calories he buzzed. He does not eat after 11am unless he has to meet people socially and eat at 7pm just at 7pm just to keep them quiet. He sleeps at about 20:30, alone. Also read: Manu Joseph: How language may have consumed to keep people unfit, I know he has high standards for himself, because he recently visited Delhi, probably out of ignorance, and refused to breathe the air for too long. Some of the most important things he did on himself was to take small amounts of Rapamycin, a drug mainly used to prevent the body’s rejection of organ transplants. It does not have approval as a medicine against aging, although it is generally believed to have potential for it. The compound has expanded the life of mice and worms beyond ambiguity and also from other animals. Johnson was the most famous human test topic. Rapamycin was probably the world’s best shot to reach long -term youth by just hitting a pill. It is still, because science will continue. But Johnson’s verdict is a crushing blow. In September, he stopped taking it because of signs that it was harming him. In January, he wrote: “Despite the tremendous potential of pre-clinical trials, my team and I concluded that the benefits of lifelong rapamycin did not justify the sturdy side effects (intermittent skin/soft tissue infections, lipid abnormalities, glucose increases and increased heart rate). The way his body responds to the drug has also aroused him to take a recent research article seriously saying that the compound could accelerate the aging over 16 biological markers of age. A few days ago he made a video to announce the bad news. Also read: Healthcare for everyone: Do not rely solely on insurance at the moment he became public, in a logical world, ministers would have rushed to Huddles to ask, “What now?” And our phones will be surprised by “Have you heard?” And billionaires would have cleared their schedules to deal with the sadness that the likelihood of their death was higher than they hoped. But strangely enough, that’s not how people respond to the news that there is a good chance that a wonderful remedy is not one. Like many disturbing drugs, Rapamycin was accidentally discovered. In the 1960s, a group of scientists collected land from a remote island in the southeastern Pacific, Rapa Nui, also known as Easter Island. One of the scientists, Suren Sehgal, found that the soil sample contained a powerful anti -sample produced by a soil bacteria. He has grown a culture of it, and he or his company Ayerst named it Rapamycin after Rapa Nui. Soon, scientists realized that it is much more than an anti -sample. “It was a powerful immune suppressing agent and prevented the cells from multiplying,” writes Venki Ramakrishnan in his book Why We The: The New Science of Aging and Lonvity. (An Immunosuppressant -Medicide impedes the immune system of the body of mistakenly its own tissues.) There is a protein mechanism in our cells that control how they act. If nutrients are plentiful, cells grow, multiply and store fat. But if they are scarce, the cells slow down the growth and storage of fat, and rather focus on cleaning damaged parts and regain it. All living things have this, which means that evolution was very important. Rapamycin can mimic this nutritional deficiency condition, which encourages the cells to move to maintenance and recovery mode. For some reason, if cells do, it expands the lifetime of the organism. This is why it is believed that fasts are beneficial. Rapamycin essentially imitating fixed conditions. A strange thing with food is that it supports life, but eventually kills. The excess, especially affects us at the cellular level. People who are slightly short of food tend to be healthier than the gluttons. A miracle I know from close observations of Malayalee alcoholists who eat moderately is that they survive food addicts. Rapamycin can make the cells of gluttons think they are hungry. Also read: The princess who built the key ingredient of Rapamycin in India is found only on that remote Pacific Island. Peter Attia says in Outlive: “It was ominous: this exotic molecule, found only on an isolated country in the middle of the ocean, acts almost like a switch that impedes a very specific cellular mechanism in almost everything that lives. But Rapamycin does not seem to work as well in humans as in some animals. No one is sure why. You may be wondering what the fuss is about. Some people have lived past 100; We just have to study it. It is alleged that some centenary lived sincerely on wine and tasty loaves. Didn’t we all hear about the Mediterranean people and those in Okinawa? Unfortunately, most of these stories are wrong or exaggerated. Saul Newman, a researcher, wrote in the New York Times that there has been a significant decline in demands of people living over the age of 110 since the arrival of birth certificates. Most advanced age claims can be clerical mistakes and fraud. This applies to Okinawan and Mediterranean stories of longevity. We need Rapamycin to work. The author is a journalist, novelist and the creator of the Netflix series, decoupled. Catch all the business news, market news, news reports and latest news updates on Live Mint. Download the Mint News app to get daily market updates. More Topics #Healthcare #Pharma #Internet Mint Special