Scientists develop a new strategy for liver and body oral cirrhosis

Researchers from the genome Organization Center at the University of Barcelona, ​​Spain, the University of Cologne in Germany, have developed a new experimental strategy to treat scars and cirrhosis of the liver and various body organs. The experiments performed on human cells derived from the patient and animal models; The strategy was effective and not -toxic and its consequences are vice versa. The scars occur due to the secretion and accumulation of different components; Like protein known as collagen, in a vacuum between individual cells, it usually occurs in response to injuries or viruses. Excessive collagen secretion can also lead to the accumulation of fibrous tissues, which is a more serious condition, as the excessive connective tissue is formed to the extent that harms the function of the tissues and sometimes the entire organs. Treatment options are usually limited to both scars and fibrosis, as most treatments are unable to penetrate enough depth to achieve the affected areas effectively, their ability to form or repair tissues is limited. Mandar and fibrosis can affect many different tissues and organs, each with its unique environment and challenges, and there is no single treatment option suitable for everyone, and treatment options are usually ineffective because it does not get rid of excess collagen that causes fibrosis and scars. In the study; The researchers brought the “gates” to the cellular level, and the strategy works at the cellular level as it launches enough collagen, so that the tissues do not disintegrate, while protecting it from the extra amounts that weaken their function, and the new strategy the use of molecules known as peptide, to prevent collagen of the cells. These peptides are disrupted by the interaction between two protein called Tango1 and Ctage5; Both proteins are linked to each other, which is needed to carry collagen from the production of the cell to the outside, and the protein is concentrated on the exit area of ​​the endoplasmic network, which is a place in the cell where materials such as proteins are filled and transported outside the cell. The target of the exit of the endoplasmic network was impossible; Since a third of the human proteins go through it, it will probably not have many -targeted toxic effects to hinder their activity. Only recently is evidence that has some privacy of the secretory materials, and proteins look like the pieces of the mystery, and to find out how two pieces fit together, the researchers should see their forms clearly, and the protein tango1 and CTAGE5 are two large and complex proteins whose form is constantly changing. Until now, the exact structure is still unknown, which in turn means that scientists do not know how to contact it at the molecular level, which impedes the efforts to design medicine that can prevent response. The researchers have overcome this challenge using Alphafold2, an artificial intelligence program that can guess the forms of protein without the need for structural data on their 3D form. Artificial intelligence and the predictions provided by artificial intelligence to the study writers enabled the design of peptides; Which can go through the cell membrane and the reaction between tango1 and ctage5. The researchers tested peptides using natural human fibrous cells, which are the most common type of cells in the connective tissue. The peptides managed to prevent the export of collagen, which led to its accumulation in the cells, and the effect was also viable, as collagen levels increased again after the peptides were removed within a period of 48 hours. The researchers have noticed similar effects in the experiments on fibrous cells in patients with skin stiffness, which is a complex auto -immune disease characterized by velfibrose and internal organs. The researchers also tested the peptides using the thickness of the ulnar, which is a common animal model to study the development of tissues and healing wounds, and this strategy clearly reduced the collagen defeat in wound areas. The researchers then plan to determine the effectiveness of peptides in the skin of the pig, because it is very similar to the skin of humans, and they will also adjust the properties of peptides to increase its effectiveness. The researchers believe that this strategy can also be used to relieve the cosmetic effects of skin scars, to treat auto -immune diseases such as sclerosis, in addition to the healing wounds and the prevention of fibrosis.