A clinical study showed that maintaining weight loss through exercise regularly, instead of using the ‘liraglutide’ to treat type 2 diabetes and obesity, the development of atherosclerosis in adults with obesity, which is one of the main causes of cardiovascular disease. The study was conducted by researchers at the University of Copenhagen in Denmark, and included an adult suffering from obesity without diabetes, and was presented within the 61st session of the European Society for Diabetes Studies (EASD), held in Vienna during the period from 15 to 19 September. The study was also described as one of the most prominent things offered in the field of obesity and heart disease over the past few years, as it reinstates the global debate on the future of obesity treatment and fundamental questions arise as to whether the drug alone is sufficient, or is the key to heart protection still moving and physical activity? In recent years, the world has been busy with obesity and heart disease, as millions of people from Europe to America face the Middle East a growing threat to heart attacks and strokes, which is the first cause of death in the world. At the heart of discussions, a question associated with the best way to maintain weight after the loss: Should modern medicine be relied on, or is traditional exercise still the most important key to heart protection? According to the new study, the drug slotide, one of the new GLP-1 fatty medicine, managed to help lose weight and maintain it. However, its results did not show a concrete effect on reducing the development of atherosclerosis, a disease that leads directly to heart attacks and strokes. On the other hand, follow -up results showed that regular exercise – even without medication – made a clear difference in inflammatory and vascular health indicators. Obesity and heart disease As doctors began to take up the causes of death during the nineteenth and twentieth centuries, it became clear that heart disease was gradually advanced in the list of causes of death, and with the middle of the twentieth century, it became clear that heart attacks and strokes were no longer rare, but that they were no longer rare. Obesity is not just an increase in weight or an external appearance that causes embarrassment in some people, as doctors today describe it as a chronic inflammatory disease, as excessive fat cells are not inactive as they have been believed in the past, but rather small factories that launch inflammatory signals in the body. These persistent infections are weakened, although low, which lies the blood vessels and makes it more vulnerable to hardening. Data indicates that obesity is a direct factor that doubles the risk of deadly diseases; As people with them increase the possibility of coronary heart disease by up to 50%, compared to people with normal weight, and they also have the risk of high blood pressure by about 70%. While Type 2 diabetes is highlighted as one of the most dangerous consequences associated with obesity as the infection rate rises to five times, which automatically means, the risk of heart and brain clumps is doubled and the deadly consequences it can cause. This link was not clear initially; In the fifties of the last century, the first wide studies in the United States were launched, such as “Framingham’s Heart Study”, which followed thousands of individuals who participated for decades. These studies have definitely proven that an unhealthy diet, excess weight, lack of physical activity and smoking are the basic factors that cause heart disease. In the first and twenty -century, obesity has changed in what the World Health Organization describes as “the fastest infectious epidemic in the history of humanity”, and figures indicate that more than 1.9 billion adults around the world are suffering from weight gain, including 650 million with obesity. Although expectations indicate that one in five adults will suffer from obesity by 2030, with the unprecedented health, economic and social liabilities it holds. Obesity medicine has seen a remarkable transformation in the field of obesity, with the rise of medicine from the “GLP-1” category, and although this category has developed a basis for the treatment of type 2 diabetes, its effectiveness in weight loss has urged the medical circles to use it as a large pharmaceutical option. The GLP-1 hormone is naturally secreted in the intestines after eating and performing different functions; Among them, the insulin secretion stimulates when glucose rises in the blood, reducing glucagon secretion, slows the emptying of the stomach in a way that increases the feeling of saturation and affects the appetite in the brain to reduce the desire to eat. Modern medicine, such as “Lyragloid” and “Simaglotide”, is designed to simulate this hormone, and has proven to help lose weight, even in people with obesity unacceptable diabetes. ‘Lyraglotide’ was adopted with a daily dose of 3 milligrams as a medicine treatment for obesity, and clinical experiments showed that the patients who used it lost between 5% and 10% of their weight within one year, and that the medicine was given daily by the subcutaneous injection, which opened it to the door. Although the loss of weight itself is an important achievement, the broader therapeutic goals are to reduce obesity cardiovascular complications, and some previous studies have shown that this medicine reduces the risk of heart attacks and strokes in diabetics, but their direct role in the decline in the development of atherosclerosis was not clear before recent dani. Over the past five years, Europe and the United States have seen a significant increase in the description of this medication until they become the core of medical discussions over the best ways to treat obesity, and despite the concrete results exceeding traditional resources, their high costs and the necessity of continuous injection forms two most important heels on their spread on a larger scale. Global health organizations have been practicing for decades that you practice at least 150 minutes a week from moderate to extreme physical activity to maintain public health. But recent research has shown that the effect of sports simply exceeding the improvement of fitness or burning calories as it works to reorganize the important body systems extensively, making it more like a natural medicine -encompassing effect. Regular physical activity helps stabilize the lost weight to diets, increasing the basic metabolism rate, that is, the number of calories the body burns in a rest condition as it maintains the muscle mass, which limits the speed of the recovery of the lost weight and increases the ability to control obesity in the long run. Sport also improves the function of the vascular lining, which is the inner layer responsible for the contracting and extraction of the veins and reduces the levels of the extracted molecules associated with the beginning of atherosclerosis, and increases the production of nitrogen oxide that contributes to the expansion of blood vessels and the blood flow improves, and the secretion of the formation of the blood and the blood flow, Separation of the secretion of the bleeding and blood flow, and the secretion of the formation of blood vessels and blood flow, and the secretion of the inflammation ability and blood flow, and reduces the secretion, and reduces the secretion, and the blood at the same time increases the production of anti -inflammatory cytokines, which create a biological balance of biological balance. The practice of physical activity regularly improves respiratory fitness, which is a stronger indication of the same weight on heart health and longevity. It also increases the body’s sensitivity to insulin, which reduces the risk of type 2 diabetes, and it also helps to reduce triglycerides and increase useful cholesterol. An overview that included 23 studies confirmed that regular exercise reduced the total mortality rate by about 30%, and another study showed that people who have medium to high fitness between 4 and 6 years longer than non -active. Despite the clarity of these benefits, the commitment to exercise remains the major obstacle, as statistics indicate that more than a third of adults in the world do not reach the minimum recommended physical activity, which opens the door for continued complications of obesity and increased rates of cardiovascular disease. In this study, a research team from the University of Copenhagen focused on an important question: to weight loss, which is more effective in developing atherosclerosis in adults with obesity without a disease, diabetes, regular exercise or using the drug loor? The experiment was performed in a random form, which was controlled by the imaginary medicine, and included 215 participants between the ages of 18 and 65, and the percentage of women between them were 63%, and all participants had obesity with a body mass index ranging from 32 and 43 kg/square meters, but they were not at the beginning of the study. Initially, all participants underwent a low -calorie for 8 weeks diet at a rate of 800 calories per day, depending on the ‘Cambridge food plan’, and at least 195 people lost 5% of their weight, at a rate of 12% of the body weight or about 13.1 kg, which are the ones who went to the second stage. After success with the loss of weight during the first phase of the experiment, participants moved to the second phase that lasted a whole year as they were randomly divided into four different groups to assess the strategies used to judge the lost weight. The first group met only 150 minutes a week of medium physical activity to physical exercises, with an imaginary drug. The second group relied only on drug therapy by taking the drug suffering loath at a dose of 3.0 mg per day. In terms of the third group, it combined regular exercises with the treatment with the medicine linelotide. While the fourth group formed the ‘control group’, where it received only a false drug without practicing a sports program or actual medicine treatment. The researchers were not only limited to the weight alone, but rather focused on accurate biological indicators directly related to the development of atherosclerosis, including inflammatory levels such as Intercin-6 and Interferon-Jama, in addition to assessing the function of vascular lining by measuring the levels of attachment molecules. An ultrasound examination was also conducted to measure the thickness of the lining middle lining of the carotic artery, which is an accredited global indicator for early detection of the changes associated with atherosclerosis. Follow -Up continued an entire year after the initial weight loss, and during this period measurements were performed in three basic time points, with the beginning of the low -calorie -diet, the beginning of the stage of weight interview, and the end of the year period designated for the experiment, and this design could follow the changes accurately and the effect of the effect of weight, vascular health and long terms -Inflammation could follow. After a full year of follow -up -Up, the three groups managed; Only exercise, only the medicine and the medicine with exercise, all of which maintain the lost weight to the low -calorie diet, and it confirms that both regular exercises and the larglottied medicine effectively contribute to weight prevention. In analyzing inflammatory indicators, it appeared that the participants who practiced sports-whether now with or without the medicine absorbing a noticeable decrease in inflammatory levels, the average VL AK of Interleukin-6 fell by 21%, and the average interferon level-a 27%. In contrast, the group of the drug did not just appear any change compared to the control group. Exercise showed a clear positive impact on the indicators of the health of the vascular lining, as the level of the vascular suture molecule fell by 6%, and the heching molecule between the cells by 8%, while the level of the stimulant of the textile stimulant fell 12%. In terms of only the group of medicine, it has no significant statistical differences compared to the imaginary drug. The results of ultrasound examination showed that physical exercises contributed to reducing the thickness of the carotist arterial counter at a rate of -0.024 mm, reflecting a slowdown in the development of atherosclerosis. On the other hand, the group of the drug did not just appear a noticeable change in this indicator. The group, which brought together liragloid and exercise, achieved completely similar results to the sports group and provided no extra superiority that could be attributed to the drug, which indicates that the most influential factor was in this study. The data confirmed that sports and the right estedide have managed to maintain weight after the loss, but the sport is distinguished by the ability to reduce inflammation indicators, improve the function of vascular lining and reduce the thickness of the veins, while lyraglotide has no extra effect on the vital indicators associated with atherosclerosis.
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