The rejection of the cultivated members: symptoms, causes and treatment

The cultivated organs rejected one of the most complicated complications that appeared after a transplantation of a member, a stem cell or bone marrow. What does happen is a very sharp immune reaction by attacking the organ or the transplanted substance. In such cases, the cultivated organ is a foreign body and produces antibodies that damage the quality of the transplanted organ and the possibility of its success. The function of the immune system is to protect the body from harmful substances, such as: germs, toxic substances, cancer cells and of any other strange body penetrating through our body, as these substances contain special proteins that exist on their surfaces and are called antigens, and when the immune system is the presence of antigens that are not a drug cell. About the transplant to better understand the disease. It is important to understand the course of the transplant and how it is done: The transplant is a modern medical treatment through which organs or tissues are replaced by organs, parts of organs or healthy tissues. The transplanted organ can be transferred from one member to another member in the same body, or from a donor to another person, or from a living being to a person, such as the organs planted today: the kidneys, liver, pancreas, bowel, heart, lungs, bone marrow, pancreatic cells, skin, cornea and bones. An organ transplantation is a difficult and complicated process, but it forms an ideal therapeutic solution for a disease in which the affected organ has lost its ability to perform its work. Treatment through implantation improves the quality of the patient’s life and can extend his life. The defense system in the human body that protects it from contaminated and dangerous factors identifies the transplanted organ as a foreign body and falls into the body, and it gives an immune reaction that refuses to receive this transplanted body within a short time, as the formation of the immunity is obtained against the implanted organ more than 400 different protein exist. The perfect appropriate organ of the tissue suitability device in the future body, as in the same twins, is successfully recorded, and given that the suitability device is very diverse, the possibilities of compatibility between the donor and the future are very little, thus leading to the lack of understanding to the activation of the rejection mechanisms, so the result is the failure of the implantation process. The best way to overcome the refusal of the cultivated organs is permanent and ongoing treatment with medicines that impede the work of the immune system, and this anti -refusal medicine prevents the transplanted organ from refusing and ensuring it remains for a long period of time. The transplant operation is characterized by measures to be taken to reduce the duration of the accumulated irregularity from the moment the transplanted organ is separated during the surgery of the blood flow and transferred to the center in which the patient is most suitable for receiving the organ and to the moment of his blood vessels. The organ stores and sprays it in the observer cool and special fluids to reduce the occurrence of devastation in the cells and from the production of free roots that reduce the damage to the organ due to the lack of blood flow in IT temporarily. Where there can be a major improvement and progress in the methods and methods of transplant operations, shortening the time of storage and attributable treatments for rejection, and although there is no complete compatibility in the tissue suitability device, the success rate of transplant operations in general and the cultivation of the kidneys has a very high degree to this treatment. When does the cultivated members reject? The worst rejection of the cultivated organs usually occurs immediately after surgery as it occurs from the birth of the type of donor at the recipient of the recipient or is obtained against the organ tissue. In the long run, the return of the initial disease or the decrease in blood flow in the implanted organ is due to the blockage of the small blood vessels or due to chronic rejection. Causes and risk factors that reject the cultivated organs. The immune system usually protects the body from substances that can be harmful, such as: germs, toxins and sometimes cancer cells. These harmful substances contain proteins called antigens that cover their surfaces, and as soon as these antigens enter the body, the immune system realizes that it is not of the person of that person and that it is strange and attacks them. If someone receives a member of another person during transplant operations, this person’s immune system knows that he is strange; This is because the person’s immune system discovers that the antigens in the cells of the organ are different or are not identical, as the non -identical organs or non -identical organs can adequately perform with the interaction of refusing the transplant. To prevent this interaction, write or fit doctors each of the organs of the organs and the person who receives the member, the more the antigens are the similarity between the donor and the recipient, the less it tends to reject the member. Doctors use medicine to impede the recipient’s immune system to prevent the immune system from attacking the newly implanted organ when the organ is not now identical. In the event that this medication is not used, the body will release an immune response and destroy exotic tissues. However, there are some exceptions, and the corneal transplants are rarely rejected; Since the cornea does not contain blood supply, the transplants are also not rejected from almost identical twins. Complications of the cultivated organs of the transplanted organs can be associated with high mortality rate and can lead to different complications, including: kidney failure. Liver failure. Chronic lung disease. Pancreatic insufficiency. arteriosclerosis. Blood disease. Criminal viral infection and infectious diseases caused by bacteria, virus or fungi. The development of malignant crops is a late complication of the rejection of chronic organ. For example, the prevalence of lymphomatic cancer is about 40 times greater at the recipient of agriculture compared to the general population due to the activation of the Epstein-Barr virus, and other crops that can be observed skin cancer and lymphoma. The diagnosis of the cultivated organs contains the most important diagnostic methods of the following: 1. The physical examination will examine the area around the implanted organ, as the signs indicating that the organ does not work the following: for example, high blood sugar when the pancreas is planted. Relating less urine as you implant the kidneys. Numbness of breath and a lack of ability to exercise when planting a heart or transplanting the lung. To perform the color of the skin and the ease of bleeding when you implant the liver. 2.. The biopsy can confirm the biopsy of the transplanted organ that it has been rejected, as a routine biopsy is performed regularly to discover early rejection before the symptoms appear. 2.. Do some tests when suspected of rejecting the member, one or more of the following tests may be performed before the organ biopsy: Investigate the abdomen with CT scans. X -Rane breast. Eggo planning. Kidney arterial photography. Ultrasound on the kidneys. Laboratory tests for kidney or liver function. Treatment of transplanted organs of routine medication to treat the refusal of cultivated organs: corticosteroids, white blood cells, calcineurin leashes -CNIs and antibodies. These drugs have been effective in the success of the transplants, but it is not exclusive to address the rejection of the cultivated organs, and it harms immunity to infections and malignant diseases. Prevention of the refusal of the transplanted organs can prevent a very several rejection by conducting a pre -andlarged examination between the donated brooms and the candidate serum for the transplant, as the most successful rejection of the cultivated organs of the first months. The transplant, and the rejection is a decline in the performance of the implanted organ and the appearance of unlimited infections symptoms that were called in the past rejection disease an expression of the seriousness of the consequences that appeared at the time.