Genetic drugs "Hope Road" for patients suffering from sickle cell anemia

Two Americans who suffered from sickle cell anemia told the story of their struggle and got rid of many years of pain, after receiving innovative genetic treatments, which recently had licenses from health authorities in the United States. The former floor, and they are called Tesha Samwalese and Jimmy Olagir, hope to raise awareness of these genetic treatments so that others can use it, especially because its cost can amount to $ 3.1 million per person. Patients with sickle cell anemia have a mutation that affects hemoglobin, which is a protein that carries oxygen in red blood cells, which then has a sickle form, which limits blood flow and produces oxygen. Poord anemia is a genetic disease that affects about 100,000 people in the United States and 20 million people worldwide, as it affects people with brown skin in particular, as scientists attribute one of the reasons for protecting the character of the sickle cell against malaria. The treatment of “Levijiia” and Tisha Samwalese was born in 1982 before newborns began for sickle cell anemia, but her injury was diagnosed at the age of two. At the age of seven, she had a dangerous seizure on anemia, and at the age of 13, a stroke forced her to undergo monthly blood transfusion. When Samuels became a young woman, she lost a friend of hers, who was a fighter of Sekelle blood poverty, and often ended up in the same hospital where she was treated. The young woman continued her studies at the prestigious ‘Howard’ University in the hope of becoming a doctor, but she was forced to leave the study because of her illness, saying that the disease ‘led her to give up dreams’. After her marriage at an early age, Tisha needed 8 o’clock injection every night, but in 2018 her life took a new turn as she became one of the first to receive experimental treatment at the time. This treatment, which is currently marketed as ‘bodygenia’, uses a virus that is not harmful to wearing a healthy version of the gene that produces hemoglobin in the cells. Doctors first collect the stem cells of the patient, and then the difficult part, namely to remove stem cells from the patient’s spinal cord through the path of chemotherapy, allow the space for modified cells. Tesha lost her hair and entered the hospital for 16 hours bleeding, then she regained her energy and said it “like getting back to life”. The platelets take months to return to normal, as every patient participating in the clinical experiment is subject to a 15 -year -old follow -follow -up. ‘Crisper’ scissors and young Jimmy Olagir (38 years old), a similar background, because his first memories are due to his illness when he was eight years old, and then he plays football in Nigeria, his original homeland, but he was forced to stop and drink every 5 minutes. After a while, his parents sent him to live with his aunt in New Jersey in the United States, where health care was better, but he lived a difficult childhood because he did not complete his studies and removed bitterness and had a heart attack. In his worst, 80% of his time in bed, but his transfer to Atlanta, where the atmosphere is warmer, helped him, as is the case for many sickle cells. In 2019, when he heard of a clinical trial using the molecular “crisis” scissors, he recorded himself and received a ‘magical’ message he predicted by accepting this experience. Thanks to the amended stem cells it receives with this treatment called “Casgeen”, Jimmy is now “Lives a Dream”. He became the father of 3 children, thanks to the enrichment in the laboratory, because he runs several small businesses, because he seeks to generalize this treatment, especially in Africa, where it is still a ‘longtime dream’. John Tesdal of the American Institutes of Health (NIH), which led to the experiment in which Tisha Samwalese participated, said the next step is to make the treatment less burden and costs for patients, and point out a fog to cover these genetic treatments by private health insurance, but the Medicaid -General program announced the following year.