A study revealing: Small molecules in the brain can fight obesity

A recent study conducted by researchers at the Canadian University of Montreal Hospital Research Center revealed that ‘Endocannabinoid’, which is small particles in the brain, plays a major role in organizing appetite and energy consumption, which opens the door for new anti -observance strategies. The endocanabinoids are small chemical molecules produced naturally by the body, and they play an important role in organizing very important processes as it is part of the nervous system, and it also affects different functions in the body, such as mood, pain, sleep and energy. The study focused on the effect of one of the molecules known as “Aradeonuel Gliesrol”, which is detached by an enzyme called “AHD6” (ABHD6), which also plays an important role in the regulatory and appetite in the brain. The importance of inhibiting the ABHD6 enzyme in a previous study has proven researchers that the inhibition of ABHD6 enzyme at body level can reduce the weight and protect against diabetes. When researchers injected targeted inhibitors of these enzyme into mice brain, their weight gain and obesity could be completely prevented. But the inhibition of this enzyme has partly led to the rise of a large group of side effects; Among them are suicidal tendencies and severe depression. In the new study, the researchers showed that the disruption of the enzyme in the “Makkat nucleus” area in the brain of mice, a region rich in endocanabinoids and the appetite and physical activity affects, reduces the motivation to eat and increase the physical activity without observing side effects. The researchers believe that manipulating the activity of this enzyme can be an effective way to control weight and physical activity without negatively affecting the mood or causing symptoms of depression and anxiety, a problem that has appeared in previous experiments aimed at cannabinoid receptors. The researchers said that the disruption of these enzymes makes the mice less desire for food and is more interested in physical activity as they spent more time running the walking wheel compared to the control group, which became obese and ethical. When the work of this enzyme inhibits or stops in the brain of mice, the levels of “arachidonylglycerol” have increased in the brain, reducing their desire to eat and increases their interest in physical activity. And when this enzyme stops working, the “Aradeonwell Gleisrol” molecule remains more active in the brain, which helps reduce weight and increase the activity. Specific neurological pathways in the brain The study shows the importance of the target of specific neurological paths in the brain to control weight, as the inhibition of the enzyme according to the targeted area can lead to conflicting effects. In 2016, researchers showed that the inhibition of the ABHD6 environmental activity in certain neurons in a sub -pinger area makes mice resistant to weight loss, while modern research has shown that inhibiting the enzyme by the brain reduces the weight gain caused by a high -fat diet. One of the most important aspects of this study is also that the mice in which the gene responsible for this enzyme showed no signs of anxiety or depression. The researchers pointed to the importance of this discovery due to the serious psychological side effects associated with the drug “rimonabant”, a previous weight loss medicine that targeted canabinoid receptors in the central nervous system and withdrew from the market due to reports of depression and suicidal tendencies. The researchers believe that these results pave the way for new obesity and metabolic disorders such as type 2 diabetes. Although ABHD6 identifies are currently being investigated, the question remains as to whether the target mechanisms in mice will apply to people. This study highlights the progress made to understand how endocanabinoids influence food behavior and physical activity, which is a promising step in the direction of safe and obese treatments.