A study that sets out the reasons for the failure of immunotherapy in eliminating cancer

A new scientific study to explain the reason for the failure of ‘immune’ t cells in the effective fighting cancer, especially in cases of chronic lymphococcal leukemia. The study shows for the first time that cancer cells cause a serious energy crisis in T -cells, disrupting their ability to attack crops, and the acute energy crisis in T -cells causes a failure, or an imbalance in the ability of these cells to produce, or the energy needed to perform their immune functions effectively. The immune system and cancer cells and T -cells play a major role in the immune system as it identifies and attacks cancer cells or other pathogens. To make these cells work correctly, you need sufficient energy, which is mainly generated by the internal metabolism process, especially by Mitochondria, responsible for energy production. The ability of T -cells is influenced by the uptake of essential nutrients such as cholesterol and fats when the cells interact with cancer cells, as in the case of chronic lymphic blood label, and these elements work as an important fuel to enable TT cells to multiply and divide, after the cancer cells are a goal for them. However, communication with cancer cells disrupts this process, leading to a lack of energy needed to perform their immune functions. Mitochondria is also damaged, leading to a significant decrease in energy production. Total cells, and in the case of an energy crisis, lose their ability to multiply and divide, which is an effective attack to effectively attack cancer cells, and the immune response becomes weak, and is unable to carry out a strong attack against the crop, which can spread cancer without adequate resistance. If the energy is missing, the cells may die, or become completely ineffective, which makes the situation worse and makes the treatment more difficult. Ti cells can be compared to a battery that is needed to work on continuous charge, and if this battery is empty, or broken, the device (T -cell) cannot work, and in the case of T -cells, ‘delivery’ means sufficient energy by mitochondria and proper metabolism, and without this charge, t -cells cannot perform their immune bags. Chronic lymphococcal leukemia is the most common kind of leukemia in the Western world, and it particularly affects the elderly, and despite recent developments in treatments, the disease is still not curable, and the cost of treatment is huge. The latest treatments, such as modified T -cell therapy, show promising results in some types of cancer, such as chronic leukemia, but it only succeeds in 15% of chronic lymphococcal leukemia patients, at a cost of more than 250 thousand dollars per patient. The immune response and the new research reveal two basic mechanisms that explain the reason for the failure of the T -cells to fight cancer effectively, especially in cases of chronic lymphococcal leukemia. In the normal state, healthy T -cells absorb large amounts of cholesterol and fat after identifying their goals, such as cancer cells; These substances are considered the basic fuel that T -cells must reproduce and divide, enabling them to carry out an effective attack on cancer cells, and this metabolic process is needed to ensure the ongoing immune response, and the ability of T -cells to eliminate crops. On the other hand, T -cells do not perform this important process when you have direct contact with chronic lymphocytes; Instead of absorbing cholesterol and fats and using them as fuel, T -cells are negatively affected, leading to the disruption of mitochondria, which is responsible for energy production in the cell. As a result, T -cells lose their ability to produce adequate energy, which impedes their reproduction and limits its effectiveness in the attack of cancer cells. In an effort to restore the energy of T -cells, the researchers tested an already current cure that affects the energy management of the cells, and the results were promising; The drug has a significant improvement in the effectiveness of T -cell treatments, which increases the hope of improving the results of future immunotherapy. The researchers believe that this discovery not only increases the success of treatment at chronic lymphatic leukemia patients, but also opens the door to investigate strategies similar to other types of cancer in which immune cells suffer from an energy crisis. Jenny Modification and researchers are currently changing certain genes to make T -cells more resistant to cancer -divisions -effects on the process of absorbing and processing fuel. If this strategy succeeds, it can be applied to other types of cancer, as immunotherapy with immune cells is still ineffective in many types of crops. New treatments are now being tested in the context of an international clinical trial, combining a drug that reduces the number of leukemia cells, and a treatment that attracts T -cells to cancer cells. Initial results have shown that this approach significantly increases the effectiveness of immunotherapy. The researchers believe that the interaction between cancer and immune cells deeply affects metabolism, which disrupts the supply of energy needed for the function of immunity, because scientists hope to develop new strategies to improve immunotherapy.