A study that reveals a promising method for the treatment of atrophic sclerosis

In a promising step in the way of understanding and treating atrophic lateral sclerosis; A new scientific study conducted by American Western Reserve University has revealed a possible treatment objective that can open the door for new strategies to combat this devastating neurological disorder. The study, published in the journal “Molkuler Midisen”, used stem cells derived from the atrophic lateral sclerosis patients to identify a gene responsible for the tension that motor neurons exercise, and managed to disrupt a laboratory, which to some of their ability to survive. The atrophic lateral sclerosis, also known as Legijal’s disease, is to this day one of the non -healing neurological diseases, and affects the motor neurons in the brain and spinal cord, leading to a gradual loss of the ability to move and breathe. Despite the great efforts to develop new treatments, many clinical tests have failed due to the major difference in the response of patients to treatments and the trouble of predicting the course of the disease. The new study, led by Helen Christina Miranda, a professor of genetics and genomic science at the Faculty of Medicine at the Kis Western University, relied on the technique of multi -capacity that caused stem cells. The multi -capabilities induced stem cells are revolutionary technology in renewal medicine and medical research, which enables the conversion of ordinary body cells, such as skin cells or blood, into stem cells that are able to convert into any kind of body cells by reprograming physical cells by studying specific genes that give scientists to the cell level. This technique is increasingly used for the mixture of complex genetic diseases, such as atrophic lateral sclerosis; Where neurons affected by real patients can be developed in the laboratory, which can test the effects of genetic mutations and medicines in a similar environment. Thanks to this technique, special treatments for each patient can also be designed based on his genetic formula, which opens the door for more accurate and effective clinical trials. In the new study; Create these cells in the laboratory based on skin cells or blood for a patient with atrophic lateral hardening, and then convert them into a specific type of cells – in this case kinetic neurons – with the aim of studying the disease in a real cellular environment derived from the patients themselves. Jean disruptions The researchers focused on a rare form and heredment of the atrophic lateral sclerosis caused by a boom in a gene known as VAPB responsible for the production of protein that helps communicate between the various cell parts, especially between the endoplasmic network and mitochondria. These two parts are essential in the cell; The first job as a quality control center to produce proteins and adjust cell performance during tension, and the second is a power plant; But in the cells of patients with this mutation, scientists have discovered that the communication between them is disrupted, leading to excessive and permanent activation of a cellular defense mechanism, known as “the integrated response to pressure, and although this response is in principle useful, but its continuation harms the production of protein and ultimately the survival of the have.