Protein can return to the patients of Alzheimer's

Alzheimer’s disease causes the gradual loss of memory, and yet there is no remedy that can help restore the lost memory, although the newly approved medicine is some hope to slow down the course of the disease; However, it does not restore the lost memory. A new study published in the journal “Clinical Investigations” emphasizes a protein that can be used to use again. Most current research focuses on creating medicines that reduce the toxic protein associated with the disease; Like the Tao protein and the beta amyloid, which accumulates in the brain with the progress of the disease. An alternative path in that new study; The researchers examined a different path instead of trying to reduce toxic protein in the brain; Try to prevent the damage caused by Alzheimer’s disease to repair the memory. The work depends on the examination of the role of a protein found in the kidneys and brain, and is called cibra. In the brain, the protein is mainly centered in neurons, which are the bonds between neurons that enable the formation and recycling of memories, and play a decisive role in transferring signals between neurons, and it is essential for processes such as learning and memory. The team found that the brains with Alzheimer’s disease suffer from a lack of kipra protein. Here; The researchers asked how the low levels of kipra affect signals in the nerve clamp, and whether a better understanding of this mechanism can create a successful method that enables them to restore the damaged nerve clamps due to Alzheimer’s disease. How is the memory formed? The memory composition is a complicated process that includes 3 different stages that require a high level coordination between the neurons in the brain. In the first phase; This is known as coding, during which the information received from the external environment, through the senses, such as vision, hearing or touch, is converted into a nerve code that the brain can treat. thereafter; Neurological signals are transferred to specific parts of the brain, where information is treated, and are converted into a stored form. Once the information is encrypted, the role of the second phase is, which includes the combination or installation of information for long -term storage. This process includes strengthening the whirlwind connections between neurons; During the merger process, the nerve circles in memory are reinforced by regular activation, and new proteins are made to support the formation of stable memory effects. As for the last phase, it is the recycling stage; What occurs through different signals or incentives, and each time the memory is detected, it may be subject to the reintegration process, which includes the setup and adjustment of memory detection based on new information or experiences. To implement the three phases; The brain needs a ‘neuropathic’ that represents the ability of nerve clamps and connections between nerve cells, to improve or be weak over time. Alzheimer’s patients lose the brain; They cannot correct the information properly; Nor can they pick it up because of the brain’s inability to get rid of toxic protein; Tau protein and beta -amyloid molecules. The absence of “Cibra” and according to the new research; The absence of kipra protein also helps not to remember the process of memory. “What we have identified is a mechanism that can be targeted to restore the function of nervous clutter, and we are now trying to develop a treatment that depends on this work,” the first author of the study said, “Grant Cao”, a researcher at the US “Back” Institute and Agency, said. In the beginning; The researchers measured the levels of cibra in the infallible fluid in humans and found that the higher protein levels occur in the raomic fluid, but the lower levels in the brain are compatible with the severity of Alzheimer’s disease. They also found a direct connection between the toxic protein and the Chipra protein. The higher the levels of the first protein, the higher levels of the second, the higher the levels of the infallible fluid. The improvement of memory scientists began to investigate this phenomenon more, hoping to use Kipra as an important indication of nerve -balance and cognitive decline that can be useful in diagnosis, detecting the planning of treatment, developing the disease and responding to treatment. The team has created a brief functional version of protein to find out how cibra affects the nerve clamps. In laboratory mice that have a condition that mimics the human disease of Alzheimer’s, they have found that this protein can reflect memory weakness associated with this type of dementia. They have found that “Cibra” can save the mechanisms that improve the elasticity of nerve clamps. According to the study; The interesting thing is that Cibra has restored the function of nervousness and memory to the mice, although the problem of accumulation of the TU toxic protein. Kipra can be used as treatment to improve memory after the onset of memory loss, despite the survival of the toxin protein that has done harm, according to researchers. In addition to other treatments that already exist, or that will come in the future, the treatment that protein uses to restore nerve clamps is value to add value.