Experimental genetic treatment has succeeded in restoring the immune function of nine children with a rare and life -threatening immunological disorder known as ‘serious white grain presentations’ of the first type. This disorder is a rare genetic condition that affects one in every million people around the world, and is caused by mutations in the gene responsible for the production of protein known as CD18, which allows white blood cells to move from the bloodstream to infection sites. In the absence of this important protein, patients, most of whom are diagnosed during the first months of their lives, are exposed to a dangerous bacterial and fungal infection. People with this deviation rarely live after childhood without treatment. According to a study published in the New England Journal of Medicine on Thursday, the researchers assessed the results two years after receiving treatment for nine patients between the ages of 5 months and 9 years, in three clinical experiences in 3 California, London and Madrid hospitals. The results have shown that all children respond to excellent treatment and now live without pathological symptoms, as skin sores and acute gums associated with the disease have disappeared, and that they could fight infection like their healthy counterparts. Effective guide said that the lead author of the study, Donald Cohen, professor of microbiology and immunity at the University of California, said that these children were no longer sentenced to diagnose it as they became in good health without a serious infection or continuous visits to the hospital, due to the effectiveness of this treatment. So far, the only treatment available to patients has been a bone marrow tillage of an identical donor, but this method poses great risks, such as major risks, such as the bait against the host, where the transplanted cells attack the recipient. Its roots “, by adjusting the stem cells of the patient himself, in a clever way similar to a programming corrosion procedures for an imbalance in a computer system. Multiply and produce what their normal function can perform in the action of blood vessels and move to infection sites to combat pathogens. Stem cells, and the immune system work effectively for the necessary treatments, it can be a self -planting “the genetic defect that causes the disease. The results showed that all patients have sufficient levels of CD18 protein, with a noticeable improvement in the number of white blood cells and a significant decrease in severe infections that require hospitalization, and that no serious side effects associated with genetic therapy have been reported. The experience of 3 siblings and among the nine patients joined a long -term follow -up study, where their condition will be monitored for 15 years to assess the continuity and safety of treatment, which is currently undergoing an overview of the US Food and Drug Administration, which in turn studies his license as a biological treatment. It is noteworthy that 3 of the patients who received the treatment are brothers and sisters who are AFA (9 years), Olivia (7 years) and Landon (5 years), John and Elisia Langel -Malhpha children, who were born with severe white grain reform and suffered from regular infection and long stay in hospital in their early years. “We felt that we were having a daily struggle. Every fever, every rash, was a source of terror for us,” Elishia said. In 2020, the parents decided to participate in the clinical experience, despite moving from Ohio to Los Angeles during the Corona virus pandemic, but today children live a normal life, where they go to school and play without fear, after overcoming the disease thanks to the genetic therapy. This achievement is a milestone in the field of genetic medicine as it opens the door for treatments similar to other rare diseases. The researchers also emphasized that encouraging results gives new hope to families facing difficult diagnoses, proving that science is capable of transforming suffering into success and inspiration stories.

A groundbreaking international study led by a team from the University of Virginia Community and ‘Kings College London’ revealed that the active substance in the famous slimming medicine ‘Ozempic’ and ‘Wegovy’, known as ‘Simajlotide’, may stop the development of inflammatory fatty liver, and even in contrast to its harmful consequences. The results were published in the New England magazine, to a clinical trial that includes 800 patients from 37 countries. The fatty liver is a common liver disease associated with obesity and type 2 diabetes, as the fat accumulates in the liver, causing infections and scars that can lead to cirrhosis or failure. The disease affects about 15 million Americans, and there is currently only a single drug accredited by the food and drug administration to treat it, making it one of the most important global health challenges. Simaglotide is a drug known for its therapeutic benefits in two main fields, namely the control of blood sugar levels for people with type 2 diabetes and to help patients with obesity lose weight. This medicine works by simulating the work of a natural hormone in the body that helps regulate appetite and slow down the stomach, leading to a longer period of saturation. It also stimulates insulin secretion when blood sugar rises, while glucagon secretion that increases sugar levels. These mechanisms of “samajlotide” have made an effective remedy to manage diabetes and improve metabolic indicators, in addition to helping it with a significant weight loss when using it with a healthy diet and regular exercise. Improving liver health proves the ability of the drug to improve liver health, through various mechanisms that include reducing hepatitis by 63% compared to imaginary therapy, and improving liver fibrosis at 37% of patients. It also contributes to the improvement of weight loss, which reflects positively on metabolism and cardiovascular health, in addition to improving liver function indicators in general, with minor side effects in most cases such as light nausea, making it a promising therapeutic option for non -alcoholic fatty lew pastry. The lead author of the study, Aaron Sanyal, said these results represent a medical penetration because it provides a treatment that improves liver health, and targets the metabolic causes of the disease such as obesity and insulin resistance. Sanyal added that the ‘semagloide’ could become a new treatment option for patients, especially with the association of fatty liver disease with heart and kidney problems. The company that manufactures ‘Simaglotide’ plans to apply for the US Food and Drug Administration this year; To form the remedy formally to treat fatty liver disease. Meanwhile, researchers still follow 1,200 patients up to 5 years; To study the effect of the drug in the long run. The study confirmed that, after its success in the treatment of diabetes and obesity, “semagloide” has been proven to be a medicine with multiple benefit, as it can become the first effective medicine treatment for inflammatory fatty liver patients, giving hope to millions of patients around the world.

A new study, published in the journal “Neurology”, which is associated with the American Academy or Neurological Medicine, indicates a possible relationship between biological age and an increased risk of dementia aging. The study states that the biological age, calculated based on important indicators such as lung function, blood pressure and cholesterol levels, may be a better indication of the risk of dementia, compared to the time age alone. The researchers found that people who show a biological age greater than their actual age were more likely to develop dementia by up to 30%, compared to those whose biological age corresponds to their age, or less than that. The 14 -year study included approximately 280,918 participants from the UK, where their state of health was detected using advanced methods of biological life, dependent on blood analyzes and different member functions. The aging explained the researchers that the progress of the biological age is related to changes in the structure of the brain, such as the decrease in the size of the gray matter, which is one of the characteristic features of the dementia. However, these brain changes do not explain the relationship between advanced biological age and outdated dementia, suggesting that there are other factors that can play a role in this process. Although the study does not prove a direct causal relationship between advanced biological life and dementia, it provides strong evidence that maintaining the health of the body through a healthy lifestyle can reduce the risk of dementia. The researchers also pointed out that factors, such as diet and exercise, can positively affect the biological age, and that it can be an effective way to prevent dementia. To study a number of restrictions, including that participants were generally more aware of the health than the general population, which can affect the results that open the door to more research, to better understand how biological aging affects brain health, and it can help develop more effective protection strategies in the future.

What do soldiers eat dust for the enemy? Special attention is also paid to their diet to keep the army staff suitable for leaking the enemies. Know how the diet of soldiers is. 1. Bread and rice are the basis of each food, they provide carbohydrates to the soldiers, giving them the energy needed to work through the day. 2. Lentils and vegetables have many proteins in lentils, which make the body strong. Eating vegetables offers vitamins and minerals, which help with the fight against disease. 3.. Meat and fish that young do not eat -cattle get protein of meat and fish. It strengthens their muscles and gives strength to the body. 4. Milk and yogurt are rich in calcium, which makes bones strong. Yogurt is also good for digestion. 5. Fruit fruits contain many vitamins and antioxidants, which keep the body healthy and protect against diseases. 6. Dry dry fruits and seeds such as almonds, raisins and peanuts. These little things are a store with energy and also have essential nutrients. 7. Water water keeps the body hydrated, which works properly and does not feel tired. Click here Life & Style Click for more stories Click here

How do you get soft skin like beauty children? Some people have very soft, healthy and delicate like the skin of children. You can also get baby skin by taking some tips. Clean your skin regularly twice a day with light detergent. Avoid rubbing more, was of love. Apply a good moisturizer to your skin after bathing the right moisturizer. It will give the skin moisture and keep it soft. Always apply sunscreen before the sun prevention comes out in the sun. Strong sunlight can dry the skin. Drink plenty of water, drink plenty of water throughout the day, keep the skin hydrated from the inside, which soften it. Exfoliate the skin once or twice a week with a light scrub. This will remove dead skin cells and make the skin look fresh. Avoid hot water. If bathing with warm water, the skin can dry. Use lukewarm water. Eat nutritious diet fruits and vegetables. The vitamins and antioxidants found in it help keep the skin healthy and soft. Enough sleep is needed to get 7-8 hours of sleep daily. A lack of sleep can make the skin look lifeless. Click here Life & Style Click for more stories Click here

Why is it important to watch children? Children are foolish and cannot recognize the danger. They can avoid accidents and injuries by watching. Children do not know right and wrong. Under the supervision of elders, they learn good things and stay away from bad habits. By paying attention, the needs of children are known, as they should learn or what they do not have. This leads to their correct development. If they pay attention to older children, they feel love and belong. This creates a strong relationship in the family. If the children are upset or have a problem, it is quickly revealed and can help on time. Children ask questions and want to know new things. If they pay close attention, they answer their questions and help them learn. Children who grow under the supervision of elders have good qualities and later become good citizens. If children are safe and happy, there is an atmosphere of happiness in the whole family. Click here Life & Style Click for more stories Click here

Health 1. Current soldiers run long distances every day, increase their physical fitness, improve mental health and also increase strength. 2. Exercise soldiers do many types of exercises like pushups, pullups and situps every day, which make their muscles strong. 3. Parade by Parade Direct Moves and Synergy is also a kind of exercise that keeps the soldiers disciplined and fit. 4. Removal of weight during exercise, soldiers must lift weapons and other heavy goods, strengthening their backs and shoulders. 5. Nutritious food eats nutritious foods, which include lentils, bread, vegetables and fruits, giving them strength. 6. They sleep in time and sleep full so that their body and spirit can relax. 7. Discipline military follows its daily routine with discipline every day, which keeps their health well. 8. Spiritual preparation, they keep their thinking strong to face difficult situations so that they can perform better physically. Click here for life and style and stories click here click here

It is very important to take care of the health of the eyes. Some houses can be very helpful in removing glasses. Turn the eyes to the top, left and round. Turn 5-10 times in each direction. Cutting of eyelids is also a good exercise. It strengthens the muscles of the eyes. Drink one teaspoon of Triphala powder in hot water before going to bed at night. It is considered beneficial to the eyes and can help increase the light. Roots are rich in beta-carotene, which is very good for the eyes. Drinking a glass of carrot juice daily can improve eye light. Week 7-8 almonds, 1 teaspoon of fennel, 1 teaspoon of sugar candy in water at night. Wake up in the morning and make a paste and eat on an empty stomach. It helps to increase the eyesight. Put a drop of pure honey in the eyes before going to bed at night. It gives relief in many eyes problems and can also help increase lights. Lightly heat Desi ghee and massage it with light hands around the eyes. It gives relief to the eyes and improves circulation. Green tea contains antioxidants that are beneficial to the eyes. If you drink a cup of green tea daily, keep the eyes healthy. Amla is a good source of vitamin C and is very beneficial for sight. You can drink cross -berry juice or eat raw Amla. Click here for life and style and stories click here click here

Stay safe in the trip during the Trending War. Waiting to calm the situation before you go. 2. Listen to the officials, listen to the talks of the police, the army or local leaders carefully and follow them. It should help you. 3.. Keep the identity with you, always keep your identity card with you. It will be very useful if necessary. 4.. Keep the essential items ready, keep food, water, first-ed set and essential medicines always ready. Keep flashlight and battery for darkness. 5.. Do not go alone as far as possible, do not travel alone. Stay with family or neighbors. 6. Stay away from unknown things, do not touch any unclaimed thing like bags or parcels and tell the authorities immediately. 7. Keep changing the way, if you have to go somewhere, do not go on the same path again and again. Use different routes to reduce the risk. 8. Keep patience, it is very important to have patience in difficult times. Help can take some time to come, so courageously. Click here Life & Style Click for more stories Click here

Kansas City, can. (AP)-Denny Hamlin said on Saturday that he remains “fairly confident” in the case brought by his 23xi races, owned by veteran driver and the retired NBA-big Michael Jordan, and front row motor sports against NASCAR, claims that antitrust violations claim. Hamlin, a day after a federal appeal panel from three judges indicated that it could reverse an order that allowed 23xi and the leading drive as chartered teams, even if their lawsuit against the stock car series plays in court. “You know, they tell me kind of what’s going on. I couldn’t hear it directly or anything, “Hamlin said after qualifying 14th for Sunday’s race on Kansas Speedway. “But we are generally quite confident in our case.” The teams filed the antitrust case against Nascar in the Western District North Carolina on October 2 with the argument that the series of teams bullied to sign charter agreements – essentially franchise transactions – making it difficult to compete financially. It was the only two holders of 15 teams holding in the charter that refused to sign the agreements in September. The most recent extension of the charter runs up to 2031, which corresponds to the current media rights agreement. The main advantage of them is perhaps that they guarantee 36 of the 40 places available in each Nascar race for teams they own. If you overturned the order, it would leave 23xi and presence as ‘open teams’, which meant they would have to qualify at each cup series. But there are only four open spots, and 23xi had four cars in Kansas this week and the front row had one. “You know, the judges didn’t make a kind of decision,” Hamlin said, “so until they do, then our status quo will stay.” Nascar lawyer Chris Yates argued that the order, which was granted by US district judge Kenneth Bell in December, forced the series to an unwanted relationship with reluctant partners, and that it harms other teams because they make less money. He also said that the teams should not have the benefits of the charter system to reverse. “There is no other place to compete,” Jeffrey Kessler, the lawyer representing 23xi and leading row, counteracted and pointed out that the reversal of the order would cause tremendous damage to the teams, which may include the loss of drivers and sponsors. “It will turn the devastation in the middle of the season,” Kessler said. There is a trial date for December, and Judge Steven Aares requested the sides to meet for mediation – previously ordered by a lower court – to resolve the dispute over the order. But that seems unlikely. “We’re not going to rewrite the charter,” Yates told the judges. ___ Associated Press author Mike Barber in Richmond, Virginia, contributed to this report. ___