Most people ignore itchy hands and feet, mistaking it for dry skin, allergy or minor irritation. But if itching persists for no apparent reason, and there is no skin rash, it could be a sign of a deeper internal problem. Doctors say that itching in the palms of the hands and soles of the feet can be an early sign of liver disease. When liver function declines, bile acids accumulate in the body, irritating skin nerves and causing intense itching. If this itching worsens at night, does not subside with moisturizers, or is accompanied by fatigue and jaundice-like symptoms, it is important to consult a doctor immediately. Why do feet itch? When the liver is not functioning properly, toxins and bile acids accumulate in the blood. These things affect the nerves of the skin, causing intense and persistent itching in the palms of the hands and soles of the feet. This type of itching is called “cholestatic pruritus” and can sometimes occur without a rash. This condition is often seen in various diseases, including primary biliary cholangitis, primary sclerosing cholangitis, and intrahepatic cholestasis during pregnancy. Why does itching occur in liver disease? Scientists are discovering these hidden causes. Scientists have not yet been able to identify any single cause of itching associated with liver disease. Experts believe that many different factors play a role in this. Accumulation of bile salts: When the liver is weak, the bile salts in the body cannot be filtered properly and begin to accumulate under the skin. It affects the nerves and can cause severe itching. However, it is also true that many people do not feel itching despite elevated bile salt levels, while others experience itching even when levels are normal. Elevated histamine levels are found in many patients with liver-related pruritus. But the interesting thing is that antihistamines often do not provide relief. Role of serotonin Serotonin can increase the feeling of itching in the brain. Some research suggests that it enhances the itching sensation by affecting specific receptors in the nervous system. Therefore, it can sometimes be difficult to treat itching in liver disease. Pregnancy or hormone therapy Hormonal changes that occur during pregnancy or hormone replacement therapy can increase itching. It is also linked to changes in bile flow in the liver. How to recognize itching related to liver? According to a study published in the National Library of Medicine, itching that lasts longer than six weeks is considered chronic pruritus. There are some differences between general itching and itching caused by liver itching, such as: Itching without a rash It increases at night It starts on the hands and feet Ways to reduce itching Do not scratch your skin too much; This can cause infection. If you have a habit of scratching at night, wear light gloves while you sleep. Bathe with lukewarm or cold water, avoid hot water. Use a room humidifier in cold weather.